Conformation of Biological Molecules New Results from NMR

Conformation of Biological Molecules New Results from NMR / by G. Govil, R. V. Hosur.

The determination of the three-dimensional structure of a biological molecule is the starting point in the understanding of molecular mechanisms involved in its complex biochemical reactions. The molecular architecture of multimolecular systems such as membranes and chromosomes provides the key to t...

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Bibliographic Details
Main Authors: Govil, G. (Author), Hosur, R. V. (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1982.
Edition:1st ed. 1982.
Series:NMR Basic Principles and Progress, 20
Springer eBook Collection.
Subjects:
Analytical chemistry.
Biophysics.
Biological physics.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 General Theory
  • 1.1 Introduction
  • 1.2 What is Conformation?
  • 1.3 Conformational Theory
  • 1.4 Structure of Long-Chain Polymers
  • 1.5 Problems in NMR Studies of Biological Molecules
  • 2 NMR Techniques in Conformational Studies
  • 2.1 Coupling Constants
  • 2.2 Chemical Shifts of Hydrogen-Bonded Protons
  • 2.3 Magnetic Anisotropy of Chemical Bonds or Groups
  • 2.4 13C Chemical Shifts
  • 2.5 31P Chemical Shifts
  • 2.6 Relaxation Times (T1 and T2)
  • 2.7 Nuclear Overhauser Effect
  • 2.8 Paramagnetic Reagents
  • 2.9 Use of Liquid Crystals as Solvents
  • 2.10 Deuterium Quadrupole Coupling Constants
  • 2.11 Solvent Accessibility
  • 2.12 From NMR Parameters to Spatial Structures
  • 3 Nucleosides, Nucleotides and Nucleic Acids
  • 3.1 Description of Nucleotide Structures
  • 3.2 Glycosidic Bond Rotations
  • 3.3 Sugar Ring Conformation: Pseudorotation
  • 3.4 Backbone Angles
  • 3.5 NMR Studies on Nucleosides
  • 3.6 Small Nucleotides
  • 3.7 Dinucleoside Phosphates and Short Segments of Nucleic Acids
  • 3.8 Random-Coil Polynucleotides
  • 3.9 Helical Polynucleotides
  • 3.10 t-RNA
  • 3.11 Drug-Nucleic Acid Interactions
  • 4 Amino Acids, Peptides and Proteins
  • 4.1 Description of the Structure of Peptide Units
  • 4.2 Theoretical Considerations. The ø, ? Maps
  • 4.3 NMR Techniques in the Study of Peptide Conformations
  • 4.4 Conformations of Amino Acids
  • 4.5 Linear Peptides
  • 4.6 Cyclic Peptides
  • 4.7 Homopolymeric Peptides. Helix-Coil Transition
  • 4.8 Characterization of Protein Structures by NMR
  • 4.9 Protein-Nucleic Acid Interaction
  • 5 Polysaccharides
  • 5.1 Structures of Polysaccharides and Carbohydrates
  • 5.2 Conformations of Monosaccharides
  • 5.3 Conformations of Polysaccharides
  • 5.4 Glycoproteins and Peptide-Carbohydrate Interactions
  • 6 Lipids and Molecular Organization in Membranes
  • 6.1 Biomembranes
  • 6.2 General Properties of Phospholipids
  • 6.3 Conformations of Phospholipids
  • 6.4 Membrane Organization and Fluidity
  • 6.5 Lipid-Protein and Lipid-Cholesterol Interactions
  • 7 Acknowledgements
  • 8 References
  • 9 Appendix
  • 10 Subject Index.

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