The 4-Quinolones: Anti Bacterial Agents in Vitro Antibacterial Agents in Vitro

The 4-Quinolones: Anti Bacterial Agents in Vitro Antibacterial Agents in Vitro / edited by Geoff C. Crumplin.

The 4-quinolone antibacterial agents have been under development and in use for over 25 years, but despite an enormous body of research work there are still many basic questions that remain unanswered. For example, we do not know how these agents kill susceptible cells - or even how the drugs intera...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Crumplin, Geoff C. (Editor)
Format: eBook
Language:English
Published: London : Springer London : Imprint: Springer, 1990.
Edition:1st ed. 1990.
Series:Springer Series in Applied Biology,
Springer eBook Collection.
Subjects:
Microbiology.
Medical microbiology.
Cell biology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 Quinolones as Broad-Spectrum Agents
  • 2 Effects of Physiological Cation Concentration on 4-Quinolone Absorption and Potency
  • 3 The Influence of Oxygen upon Bactericidal Potency
  • 4 Interactions of 4-Quinolones with Other Agents — the Importance in Assessing Practical Antibacterial Potency
  • 5 Molecular Effects of 4-Quinolones upon DNA Gyrase
  • 6 Mechanisms of Killing of Bacteria by 4-Quinolones
  • 7 Use of an in vitro DNA Strand-Breakage Assay to Monitor Compound Interactions with DNA Gyrase
  • 8 Comparisons of DNA Gyrases from Different Species
  • 9 Structure-activity Relationships of Fluoro-4-Quinolones
  • 10 Aspects of Quinolone-DNA Interactions
  • 11 Selective Toxicity: the Activities of 4-Quinolones against Eukaryotic DNA Topoisomerases
  • 12 In vitro Genotoxity Assessment and the Effects of 4-Quinolones upon Human Cells
  • 13 Mechanisms of Bacterial Resistance to 4-Quinolones
  • 14 In vitro and in vivo Mutation Frequencies to Resistance — do they Correlate in the Long Term?
  • 15 Measurement of the Frequency of Mutation to Resistance — the Importance of Testing under Physiological Conditions
  • 16 Plasmid-borne Resistance to 4-Quinolones — a Real or an Apparent Absence?
  • Poster Presentations
  • Anaerobiosis and staphylococcal resistance to certain 4-quinolones
  • Gram Negative Mutants Resistant to 4-Quinolones: Are they Competent Pathogens?
  • Quinolone-Resistant E. Coli Mutants Overproduce a 60 kDa Protein Highly Homologous to GroEL.

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