Molecular Components of Hepatitis B Virus

Molecular Components of Hepatitis B Virus by M. Feitelson.

Since the discovery of Australia antigen and its association with type B hepatitis, molecular characterization of the components making up hepatitis B virus (RBV) have been pursued with worldwide interest. Over the past two decades, such characterization has led to the development of sensitive assay...

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Bibliographic Details
Main Author: Feitelson, M. (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: New York, NY : Springer US : Imprint: Springer, 1985.
Edition:1st ed. 1985.
Series:Developments in Molecular Virology ; 6
Springer eBook Collection.
Subjects:
Virology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Hepatitis B Surface Antigen (HBsAg)
  • Nature of the “a” determinant
  • Antigenic and immunogenic properties of HBsAg associated components
  • Host components in HBsAg particles
  • Possible vaccines lacking host components
  • HBsAg associated carbohydrate
  • HBsAg and the receptor for polymerized albumin
  • Dane Particle “Specific” Antigenic Determinants
  • Anti-HBs Monoclonal Antibodies
  • Dane Particles and Hepatitis B Core Antigen (HBcAg)
  • Anti-HBc
  • Hepatitis B e Antigen
  • HBeAg and infectivity
  • Chemical characterization
  • HBeAg activity in Dane and core particles
  • The Protein Kinase Activity in HBcAg and the Proposed Nucleic Acid Binding Properties of Core Polypeptide
  • The DNA Polymerase Activity of HBV
  • Characterization and relation to other polymerases
  • Chemotherapy
  • HBV Genome Structure and Expression
  • General physical characteristics
  • Restriction endonuclease analysis
  • Genome isomers
  • HBV in Hepatocellular Carcinoma and the Chronic Carrier State
  • HBV DNA in human hepatoma cell lines
  • HBV DNA in tumorous and nontumorous tissues
  • Karyotyping of human hepatoma cells
  • Nucleic Acid Sequencing of Dane Particle DNA and Expression of HBV Genes
  • Nature of open reading frames
  • Surface antigen gene structure and expression
  • Core antigen and e antigen gene structure and expression
  • The proposed polymerase gene of HBV DNA
  • Open region X in HBV DNA
  • The 5? Terminal Protein and Possible Origin of Genome Replication Associated with Hepatitis Viruses
  • Replication Scheme for Hepatitis B and Related Viruses
  • Conclusions
  • References.

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