Apoptosis and Cancer Chemotherapy

Apoptosis and Cancer Chemotherapy edited by John A. Hickman, Caroline Dive.

The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecul...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Hickman, John A. (Editor), Dive, Caroline (Editor)
Format: eBook
Language:English
Published: Totowa, NJ : Humana Press : Imprint: Humana, 1999.
Edition:1st ed. 1999.
Series:Cancer Drug Discovery and Development,
Springer eBook Collection.
Subjects:
Oncology  .
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 Does Apoptosis Contribute to Tumor Cell Sensitivity to Anticancer Agents?
  • 2 p53, Apoptosis, and Chemotherapy
  • 3 The Role of p53 in Chemosensitivity
  • 4 Function of the p53 Gene Family: A Holistic Perspective
  • 5 Mismatch Repair Deficiency, Apoptosis, and Drug Resistance
  • 6 Involvement of c-Abl Tyrosine Kinase in Apoptotic Response to Anticancer Agents
  • 7 Bcl-2 Family Proteins: Relative Importance as Determinants of Chemoresistance in Cancer
  • 8 Bax, a Death Effector Molecule: Its Role in Development and Oncogenesis
  • 9 Bax, a Proapoptotic Protein Forming Channels in Mitochondria
  • 10 Mechanism of Action of the Proapoptotic Gene Bak
  • 11 Killers or Clean-Up Crew: How Central Are the Central Mechanisms of Apoptosis?
  • 12 Role of CD95 (APO-1/Fas) System in Chemotherapy
  • 13 Insulin-Like Growth Factor-1 Receptor as a Target for Anticancer Therapy
  • 14 Drug Resistance and the Survival Niche: Survival Signals Combine to Suppress Drug-Induced Apoptosis in B-Lymphoma Cells
  • 15 Chemotherapy, Tumor Microenvironment, and Apoptosis
  • 16 Molecular Regulation and Therapeutic Implications of Cell Death in Prostate Cancer
  • 17 Chemotherapy and Apoptosis in the Ovary: Cancer Treatment Comes with a Price
  • 18 Role of Bcl-2 Family Members in Homeostasis, in Toxicology in Normal Intestine, and for Prognosis of Colonic Carcinomas
  • 19 Apoptosis and Breast Cancer
  • 20 Role of Apoptosis in Human Neuroblastomas
  • 21 Response of Testicular Tumors to Chemotherapy: Relative Role of Drug—DNA Interactions and Apoptosis
  • Concluding Remarks: Has the Information Explosion on Apoptosis Affected Clinical Practice?.

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