Cytochrome P450

Cytochrome P450 edited by John B. Schenkman, Helmut Greim.

In this book the editors have brought together the widest group of investigators of the cytochrome P450 superfamily in order to present complete and right up-to-date coverage of this important enzyme system. The authors describe and analyze the components of the enzyme system, the reaction mechanism...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Schenkman, John B. (Editor), Greim, Helmut (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1993.
Edition:1st ed. 1993.
Series:Handbook of Experimental Pharmacology, 105
Springer eBook Collection.
Subjects:
Pharmacology.
Biochemistry.
Endocrinology .
Oncology  .
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Section I: The Monooxygenase System
  • 1 Historical Background and Description of the Cytochrome P450 Monooxygenase System
  • 2 NADPH-Cytochrome P450 Reductase: Function
  • 3 Protein and Gene Structure and Regulation of NADPH-Cytochrome P450 Oxidoreductase
  • 4 Localization of Cytochrome P450 in Membranes: Mitochondria
  • 5 Localization of Cytochrome P450 in Membranes: Reconstituted Systems
  • Section II: The Monooxygenase Reactions
  • 6 Metabolic Reactions: Types of Reactions of Cytochrome P450 Enzymes
  • 7 Metabolic Reactions: Mechanisms of Substrate Oxygenation
  • 8 Liver Cytochrome P450 Metabolism of Endogenous Steroid Hormones, Bile Acids, and Fatty Acids
  • 9 Metabolic Reactions: Role of Cytochrome P450 in the Formation of Reactive Oxygen Species
  • 10 Cytochrome P450 Structure and Function
  • 11 Structure of Cytochrome P450: Heme-Binding Site and Heme Reactivity
  • 12 Cytochrome P450: Probes of Active Site Residues
  • 13 Structural Models for Substrates and Inhibitors of Cytochrome P450 Enzymes
  • Section III: Forms of Microsomal P
  • 14 Cytochrome P450 Evolution and Nomenclature
  • 15 Cytochrome P450 in Rodents
  • 16 Cytochrome P450 in Humans
  • 17 Avian Cytochrome P450
  • 18 Cytochrome P450 Forms in Fish
  • 19 Cytochrome P450 in Plants
  • 20 Cytochrome P450 in Insects
  • 21 Cytochrome P450 in Unicellular Organisms
  • 22 Extrahepatic Microsomal Forms: Olfactory Cytochrome P450
  • 23 Extrahepatic Microsomal Forms: Gastrointestinal Cytochromes P450, Assessment and Evaluation
  • 24 Extrahepatic Microsomal Forms: Lung Microsomal Cytochrome P450 Isozymes
  • 25 Extrahepatic Microsomal Forms: Brain Cytochrome P450
  • 26 Cytochrome P450 in Primary and Permanent Liver Cell Cultures
  • 27 Cytochromes P450 in Genetically Engineered Cell Cultures: The Gene Technological Approach
  • Section IV: Modulation of Cytochrome P450 Levels
  • 28 Genetics: Animal and Human Cytochrome P450 Polymorphisms
  • 29 Hormonal Regulation of Cytochrome P450 in Rat Liver
  • 30 Age- and Gender-Related Expression of Rat Liver Cytochrome P450
  • 31 Changes in Cytochrome P450 in Senescence
  • 32 Regulation of Cytochrome P450 Expression
  • 33 Induction of Cytochromes P450 1 and P450 2 by Xenobiotics
  • Section V: Chemical Modification, Protein-Protein and Protein-Lipid Interaction
  • 34 Protein-Protein Interactions
  • 35 Chemical Probes of Cytochrome P450 Structure
  • 36 Posttranslational Modification of Cytochrome P450
  • 37 Lipid-Protein Interactions
  • Section VI: Biosynthetic Forms of Cytochrome P
  • 38 Cholesterol 7?-Hydroxylase and 12?-Hydroxylase
  • 39 Tissue-Specific Regulation of Aromatase Cytochrome P450 (CYP19) Expression
  • 40 Lanosterol 14a-Demethylase (Cytochrome P45014DM)
  • 41 Steroid 11ß-Hydroxylase Isozymes (CYP11B1 and CYP11B2)
  • 42 Cholesterol Side Chain Cleavage Cytochrome P450 (P450scc)
  • 43 Cytochrome P450cl7: Regulation of Gene Expression and Enzyme Function at the Bifurcation in Steroid Hormone Synthesis
  • 44 25-Hydroxy vitamin D-la-Hydroxylases: An Examination of Renal and Extrarenal Sources
  • 45 Steroid 21-Hydroxylase
  • 46 Sterol 26-Hydroxylase
  • 47 Nitric Oxide Synthase (NOS).

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