Transgenic Models in Pharmacology

Transgenic Models in Pharmacology edited by Lutz Hein.

The aim of this volume is to give up-to-date information on animal models generated by transgenic or gene targeting techniques. Naturally, the focus is on the mouse system. Each chapter has been written by leading experts in the field and gives an overview on existing animal models. This is facilita...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Hein, Lutz (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2004.
Edition:1st ed. 2004.
Series:Handbook of Experimental Pharmacology, 159
Springer eBook Collection.
Subjects:
Pharmacology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1. Transgenic Techniques
  • Inducible Transgene Systems
  • 2. Molecular Systems
  • Adrenergic System
  • Muscarinic Acetylcholine Receptor Knockout Mice
  • Mouse Models of NO/ Natriuretic Peptide/ cGMP Kinase Signaling
  • Transgenic Models for the Study of Protein Kinase A-regulated Signal Transduction
  • G-Protein-Mediated Signalling Pathways
  • Analysis of Integrin Function by Gene Targeting in Mice
  • 3. Nervous System
  • Transgenic Mouse Models in the Analysis of Neurotransmitter Release Mechanism
  • Analysis of GABA Receptor Assembly and Function in targeted mutant mice
  • Neurotrophic Factors
  • Genetic Analysis of the Endogenous Opioid System
  • 4. Cardiovascular System
  • Transgenic Mouse Models of Cardiovascular Function and Disease
  • Renin-Angiontensin-System/Blood Pressure Control
  • Lipoprotein Transport
  • 5. Immunology/Hematology/Inflammation
  • Transgenic Animals of Enzymes and Receptors in Prostanoid Synthesis and Actions; Phenotypes and Implications in Drug Development
  • Coagulation and Fibrinolysis in Genetically Modified Mice
  • Transgenic Animals in Primary Hemostasis and Thrombosis
  • Chemokine Receptors
  • 6. Endocrinology
  • Steroid Receptors
  • Reproductive System
  • Understanding Molecular Mechanism of Toxicity and Carcinogenicity Using Gene Knockout and Transgenic Mouse Models.

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