|
|
|
|
| LEADER |
00000nam a22000005i 4500 |
| 001 |
b3202154 |
| 003 |
MWH |
| 005 |
20191026231024.0 |
| 007 |
cr nn 008mamaa |
| 008 |
121227s2001 xxu| s |||| 0|eng d |
| 020 |
|
|
|a 9781592591114
|
| 024 |
7 |
|
|a 10.1007/978-1-59259-111-4
|2 doi
|
| 035 |
|
|
|a (DE-He213)978-1-59259-111-4
|
| 050 |
|
4 |
|a E-Book
|
| 072 |
|
7 |
|a MJCJ
|2 bicssc
|
| 072 |
|
7 |
|a MED022090
|2 bisacsh
|
| 072 |
|
7 |
|a MJCJ
|2 thema
|
| 245 |
1 |
0 |
|a Antimalarial Chemotherapy
|h [electronic resource] :
|b Mechanisms of Action, Resistance, and New Directions in Drug Discovery /
|c edited by Philip J. Rosenthal.
|
| 250 |
|
|
|a 1st ed. 2001.
|
| 264 |
|
1 |
|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2001.
|
| 300 |
|
|
|a XI, 396 p.
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 347 |
|
|
|a text file
|b PDF
|2 rda
|
| 490 |
1 |
|
|a Infectious Disease
|
| 490 |
1 |
|
|a Springer eBook Collection
|
| 505 |
0 |
|
|a I Introduction -- 1 The Need for New Approaches to Antimalarial Chemotherapy -- 2 The History of Antimalarial Drugs -- 3 Transport and Trafficking in Plasmodium-Infected Red Cells -- 4 The Plasmodium Food Vacuole -- 5 Clinical and Public Health Implications of Antimalarial Drug Resistance -- II Established Antimalarial Drugs and Compounds Under Clinical Development -- 6 Chloroquine and Other Quinoline Antimalarials -- 7 8-Aminoquinolines -- 8 Mechanisms of Quinoline Resistance -- 9 Folate Antagonists and Mechanisms of Resistance -- 10 Artemisinin and Its Derivatives -- 11 Atovaquone—Proguanil Combination -- 12 The Antimalarial Drug Portfolio and Research Pipeline -- III New Compounds, New Approaches, and New Targets -- 13 Novel Quinoline Antimalarials -- 14 New Antimalarial Trioxanes and Endoperoxides -- 15 Antibiotics and the Plasmodial Plastid Organelle -- 16 Fresh Paradigms for Curative Antimetabolites -- 17 Iron Chelators -- 18 Protease Inhibitors -- 19 Inhibitors of Phospholipid Metabolism -- 20 Development of New Malaria Chemotherapy by Utilization of Parasite-Induced Transport.
|
| 520 |
|
|
|a At a time when the control of malaria is increasingly limited by the growing resistance of malaria parasites to available drugs, the need for a much better use of the existing drugs, as well as for the development of new antimalarials, has become urgent. In Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery, a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. The survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, and new chemical approaches to and possible new targets for chemotherapy. It also discusses, as essential background, the history of chemotherapy, the practical aspects of therapy, and the public health consequences of current problems in antimalarial chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.
|
| 590 |
|
|
|a Loaded electronically.
|
| 590 |
|
|
|a Electronic access restricted to members of the Holy Cross Community.
|
| 650 |
|
0 |
|a Infectious diseases.
|
| 690 |
|
|
|a Electronic resources (E-books)
|
| 700 |
1 |
|
|a Rosenthal, Philip J.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 830 |
|
0 |
|a Infectious Disease
|
| 830 |
|
0 |
|a Springer eBook Collection.
|
| 856 |
4 |
0 |
|u https://holycross.idm.oclc.org/login?auth=cas&url=https://doi.org/10.1007/978-1-59259-111-4
|3 Click to view e-book
|
| 907 |
|
|
|a .b32021549
|b 04-18-22
|c 02-26-20
|
| 998 |
|
|
|a he
|b 02-26-20
|c m
|d @
|e -
|f eng
|g xxu
|h 0
|i 1
|
| 912 |
|
|
|a ZDB-2-SME
|
| 912 |
|
|
|a ZDB-2-BAE
|
| 950 |
|
|
|a Medicine (Springer-11650)
|
| 902 |
|
|
|a springer purchased ebooks
|
| 903 |
|
|
|a SEB-COLL
|
| 945 |
|
|
|f - -
|g 1
|h 0
|j - -
|k - -
|l he
|o -
|p $0.00
|q -
|r -
|s b
|t 38
|u 0
|v 0
|w 0
|x 0
|y .i21153188
|z 02-26-20
|
| 999 |
f |
f |
|i fe3e5800-b752-5c3e-be01-50bd1c7b7f39
|s bc2b5604-5e6d-52d9-b5e5-e9d6a9d97cbf
|
| 952 |
f |
f |
|p Online
|a College of the Holy Cross
|b Main Campus
|c E-Resources
|d Online
|e E-Book
|h Library of Congress classification
|i Elec File
|n 1
|