Antimalarial Chemotherapy Mechanisms of Action, Resistance, and New Directions in Drug Discovery

Antimalarial Chemotherapy Mechanisms of Action, Resistance, and New Directions in Drug Discovery / edited by Philip J. Rosenthal.

At a time when the control of malaria is increasingly limited by the growing resistance of malaria parasites to available drugs, the need for a much better use of the existing drugs, as well as for the development of new antimalarials, has become urgent. In Antimalarial Chemotherapy: Mechanisms of A...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Rosenthal, Philip J. (Editor)
Format: eBook
Language:English
Published: Totowa, NJ : Humana Press : Imprint: Humana, 2001.
Edition:1st ed. 2001.
Series:Infectious Disease
Springer eBook Collection.
Subjects:
Infectious diseases.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • I Introduction
  • 1 The Need for New Approaches to Antimalarial Chemotherapy
  • 2 The History of Antimalarial Drugs
  • 3 Transport and Trafficking in Plasmodium-Infected Red Cells
  • 4 The Plasmodium Food Vacuole
  • 5 Clinical and Public Health Implications of Antimalarial Drug Resistance
  • II Established Antimalarial Drugs and Compounds Under Clinical Development
  • 6 Chloroquine and Other Quinoline Antimalarials
  • 7 8-Aminoquinolines
  • 8 Mechanisms of Quinoline Resistance
  • 9 Folate Antagonists and Mechanisms of Resistance
  • 10 Artemisinin and Its Derivatives
  • 11 Atovaquone—Proguanil Combination
  • 12 The Antimalarial Drug Portfolio and Research Pipeline
  • III New Compounds, New Approaches, and New Targets
  • 13 Novel Quinoline Antimalarials
  • 14 New Antimalarial Trioxanes and Endoperoxides
  • 15 Antibiotics and the Plasmodial Plastid Organelle
  • 16 Fresh Paradigms for Curative Antimetabolites
  • 17 Iron Chelators
  • 18 Protease Inhibitors
  • 19 Inhibitors of Phospholipid Metabolism
  • 20 Development of New Malaria Chemotherapy by Utilization of Parasite-Induced Transport.

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