Vertebrate Red Blood Cells Adaptations of Function to Respiratory Requirements

Vertebrate Red Blood Cells Adaptations of Function to Respiratory Requirements / by Mikko Nikinmaa.

This book reviews the respiratory function of vertebrate red cells. I have defined the phrase "respiratory function" broadly to include, in addition to the actual oxygen and carbon dioxide transport, erythropoiesis, haemoglobin synthesis, red cell structure, the deformability of red cells...

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Bibliographic Details
Main Author: Nikinmaa, Mikko (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1990.
Edition:1st ed. 1990.
Series:Zoophysiology, 28
Springer eBook Collection.
Subjects:
Zoology.
Biochemistry.
Cell biology.
Biophysics.
Biological physics.
Hematology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1. Introduction
  • 2. Erythropoiesis and the Control of Circulating Red Cell Number
  • 2.1 Erythropoietic Sites
  • 2.2 Mammalian Erythropoiesis
  • 2.3 Erythropoiesis in Nonmammalian Vertebrates
  • 2.4 Senescence of Red Blood Cells
  • 2.5 Erythropoiesis-Independent Factors Increasing Circulating Red Cell Number
  • 3. The Biosynthesis and Structure of Haemoglobin
  • 3.1 Uptake of Iron into Erythroid Cells
  • 3.2 Haem Synthesis
  • 3.3 Globin Synthesis
  • 3.4 Subunit Assembly of Haemoglobin
  • 3.5 Haemoglobin Structure in Vertebrates
  • 4. Structure of Circulating Red Cells
  • 4.1 General Anatomy of the Cell
  • 4.2 The Red Cell Membrane
  • 5. Red Cells in Circulation: Factors Affecting Red Cell Shape and Deformability
  • 5.1 Blood Viscosity
  • 5.2 Deformability of Red Cells
  • 6. Energy Metabolism and Regulation of Organic Phosphate Concentrations
  • 6.1 Energy Consumption
  • 6.2 Transport of Substrates into the Red Cells
  • 6.3 Glycolysis
  • 6.4 Pentose Phosphate Pathway and Glutathione Metabolism
  • 6.5 Krebs Cycle and Oxidative Phosphorylation
  • 6.6 Organic Phosphate Metabolism
  • 6.7 Cellular Control of Red Cell Organic Phosphate Concentrations
  • 7. Major Ion Transporting Pathways
  • 7.1 Electrodiffusive Leak
  • 7.2 Ion Channels
  • 7.3 Anion Exchange
  • 7.4 Ion Transport Coupled to Sodium or Potassium Gradient
  • 7.5 Active Transport
  • 7.6 Membrane Potential
  • 8. Control of Volume and pH
  • 8.1 The Basic Model: Control of Red Cell pH and Volume in the Absence of Significant Secondarily Active Transport
  • 8.2 Mammalian Red Cells
  • 8.3 Avian Red Cells
  • 8.4 Reptilian Red Cells
  • 8.5 Amphibian Red Cells
  • 8.6 Fish Red Cells
  • 9. Carbon Dioxide Transport
  • 9.1 Distribution of Total Carbon Dioxide Content Between Red Cells and Plasma
  • 9.2 Carbon Dioxide — Bicarbonate Equilibria
  • 9.3 Formation of Carbamino Compounds
  • 9.4 Mechanisms of Carbon Dioxide Excretion
  • 10. Oxygen Transport
  • 10.1 Haemoglobin-Oxygen Equilibria — Basic Principles
  • 10.2 Methods for Determining Blood/Haemoglobin Oxygen Content and Oxygen Equilibrium Curves
  • 10.3 Molecular Aspects of Haemoglobin-Oxygen Binding
  • 10.4 Formation and Reduction of Methaemoglobin
  • 10.5 Cellular and Molecular Adaptations of Haemoglobin Function to Variations in Respiratory Requirements
  • References.

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