Artificial Nucleases

Artificial Nucleases edited by Marina A. Zenkova.

The development of agents capable of cleaving RNA and DNA has attracted considerable attention of researchers in the last few years, because of their application in biotechnology and pharmacology. Artificial nucleases are rationally designed to imitate the active centers of natural enzymes by simple...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Zenkova, Marina A. (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2004.
Edition:1st ed. 2004.
Series:Nucleic Acids and Molecular Biology, 13
Springer eBook Collection.
Subjects:
Enzymology.
Biochemistry.
Pharmacology.
Biochemical engineering.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • DNA Hydrolysis: Mechanism and Reactivity
  • Active Site of Ribonuclease A
  • Structural Considerations Concerning Cleavage of RNA
  • Cleavage of RNA by Imidazole
  • Principles of Nucleic Acid Cleavage by Metal Ions
  • Allosterically Controlled Ribozymes as Artificial Ribonucleases
  • Small Ribonuclease Mimics
  • Copper-Containing Nuclease Mimics: Synthetic Models and Biochemical Applications
  • RNA-Cleaving Oligonucleotide-Peptide Conjugates
  • Sequence Selective Artificial Ribonucleases Employing Metal Ions as Scissors
  • Site-Specific Artificial Ribonucleases: Conjugates of Oligonucleotides with Catalytic Groups
  • DNA and RNA Cleavage Mediated by Phenanthroline-Cuprous Oligonucleotides: From Properties to Applications
  • Sequence-Specific Cleavage of Double-Stranded DNA
  • Bleomycin-Oligonucleotide Conjugates as Site-Specific Nucleases.

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