Microtubules

Microtubules by Pierre Dustin.

The decision, in 1975, to write alone a monograph on micro tubules was not without risks. While I was familiar from its start in Brussels in 1934 with the work on col­ chicine and other mitotic poisons, the literature on microtubules was, 8 years ago, already increasing at an impressive rate. Howeve...

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Bibliographic Details
Main Author: Dustin, Pierre (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1984.
Edition:2nd ed. 1984.
Series:Springer eBook Collection.
Subjects:
Cell biology.
Biochemistry.
Neurosciences.
Allergy.
Immunology.
Oncology  .
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • From the Introduction to the First Edition
  • Acknowledgments
  • 1 Historical Background
  • 1.1 Micro tubules (MT)
  • 1.2 Colchicine: A Specific MT Poison
  • 1.3 Other MT Poisons
  • 1.4 Action of Physical Agents
  • 1.5 Conclusion
  • References
  • 2 Structure and Chemistry of Microtubules
  • 2.1 Introduction
  • 2.2 General Morphology of MT
  • 2.3 Structure of MT
  • 2.4 Biochemistry of MT and Associated Proteins
  • 2.5 Assembly and Disassembly of MT in Vitro
  • 2.6 Summary
  • References
  • 3 General Physiology of Tubulins and Microtubules
  • 3.1 Introduction
  • 3.2 Tubulin Synthesis and Its Regulation
  • 3.3 Assembly of MT in Vivo
  • 3.4 Relations of MT with Other Cell Structures and Organelles
  • 3.5 Relations with Viruses and Endocellular Parasites
  • 3.6 Extracellular MT
  • References
  • 4 Complex Microtubule Assemblies: Axonemes, Centrioles, Basal Bodies, Cilia, and Flagella
  • 4.1 Introduction
  • 4.2 Axonemes
  • 4.3 Centrioles
  • 4.4 Cilia and Flagella. Introduction
  • 4.5 Basal Bodies
  • 4.6 Regeneration of Cilia and Ciliogenesis
  • 4.7 Atypical and Pathological Cilia
  • References
  • 5 Microtubule Poisons
  • 5.1 Introduction
  • 5.2 Colchicine and Colchicine Derivatives
  • 5.3 The Catharanthus (Vinca) Alkaloids
  • 5.4 Podophyllotoxin and Related Molecules
  • 5.5 Sulfhydryl Reagents
  • 5.6 The Benzimidazole Derivatives
  • 5.7 Griseofulvin
  • 5.8 Anesthetic Drugs
  • 5.9 Other MT Poisons
  • 5.10 Taxol: An Agent That Favorizes MT Assembly
  • 5.11 Action of Physical Agents and Heavy Water
  • References
  • 6 Cell Shape
  • 6.1 Introduction
  • 6.2 Disk-Shaped Blood Cells
  • 6.3 Nuclear and Cytoplasmic Shaping in Spermatogenesis
  • 6.4 Other Cytoskeletal Functions of MT in Metazoa
  • 6.5 Egg Differentiation and Embryonic Growth
  • 6.6 Cell Shape in Plants
  • 6.7 Cell Shape in Protozoa
  • 6.8 MT with Mechanical Functions
  • References
  • 7 Cell Movement
  • 7.1 Introduction
  • 7.2 Intracellular Displacements and Motion
  • 7.3 The Movement of Pigment Granules
  • 7.4 Movements of Cell Membranes and “Capping”
  • 7.5 Cell Motility and Locomotion
  • 7.6 Ciliary Movements
  • References
  • 8 Secretion
  • 8.1 Introduction
  • 8.2 Endocrine Secretions
  • 8.3 Exocrine Secretions
  • 8.4 Leukocytes and Related Cells
  • 8.5 Other Cell Activities Related to Secretion
  • 8.6 Conclusions
  • References
  • 9 Neurotubules and Neuroplasmic Transport
  • 9.1 Introduction
  • 9.2 General Properties of Nerve MT
  • 9.3 Relations of MT with Synaptic Vesicles
  • 9.4 Microtubules and Nerve Cells Shape
  • 9.5 Experimental Changes of Neuronal MT
  • 9.6 Neuroplasmic Transport and MT
  • 9.7 Role of MT in Axoplasmic Transport
  • 9.8 Theories of Neuroplasmic Transport
  • 9.9 MT and Sensory Cells
  • References
  • 10 Microtubules and Mitosis
  • 10.1 Introduction
  • 10.2 Some Aspects of the Possible Evolution of Mitosis
  • 10.3 Some Types of Mitosis
  • 10.4 Methods of Study
  • 10.5 MT and Mitotic Movements
  • 10.6 Other Proteins Associated with Mitotic MT
  • 10.7 The Action of MT Poisons on Mitosis
  • 10.8 The Action of Physical Factors on Mitosis
  • 10.9 Microtubules and the Mechanisms of Mitosis
  • 10.10 Conclusions
  • References
  • 11 MT and MT Poisons in Pathology and Medicine
  • 11.1 Introduction
  • 11.2 Pathology of MT Structures
  • 11.3 Therapeutic Uses of MT Poisons
  • 11.4 The Toxicity of the Vinca (Catharanthus) Alkaloids
  • 11.5 Toxicity of MT Poisons in Cancer Chemotherapy 433 References
  • 12 Post-Script and Outlook
  • 12.1 Unity and Diversity
  • 12.2 Microtubule-Associated Proteins (MAPs)
  • 12.3 Assembly and Disassembly
  • 12.4 Microtubule Poisons
  • 12.5 Non-Microtubular Tubulin
  • 12.6 Micro tubules and Movement
  • 12.7 Micro tubules and Cell Shape
  • 12.8 Micro tubules and Evolution
  • References
  • Addenda Some of the Most Interesting Papers Published in 1983 and Early in 1984
  • Recent Books and Reviews on Microtubules and Related Subjects.

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