Interferon: The Dawn of Recombinant Protein Drugs edited by J. Lindenmann, W.-D. Schleuning.

Forty years of Interferon I wish to dedicate this short introduction to the memory of Alick Isaacs (1921-1967), and to that of Sir Christopher Andrewes (1896-1988). Let us go back more than 40 years. In 1956 Isaacs was in charge of the Wodd Influenza Centre. Andrewes was head of the division of bac­...

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Corporate Author: SpringerLink (Online service)
Other Authors: Lindenmann, J. (Editor), Schleuning, W.-D (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1999.
Edition:1st ed. 1999.
Series:Schering Foundation Symposium Proceedings Supplements ; 5
Springer eBook Collection.
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Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.

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505 0 |a 1 Is There Life Without Interferon? -- 2 What Constitutes Therapeutic Success? The Interferons (1978–1998) -- 3 The Prehistory and History of the Uses of Interleukin-2 in Cancer Therapy -- 4 Interferon-?: From Pass Interference to Cytokine Networking -- 5 A Biosemiotic View of Interferon: Toward a Biology of Really Living Organisms -- 6 The Clinical and Social Impact of Beta Interferon: the First Approved Therapy in Multiple Sclerosis -- 7 Closing Discussion -- Previous Volumes Published in this Series. 
520 |a Forty years of Interferon I wish to dedicate this short introduction to the memory of Alick Isaacs (1921-1967), and to that of Sir Christopher Andrewes (1896-1988). Let us go back more than 40 years. In 1956 Isaacs was in charge of the Wodd Influenza Centre. Andrewes was head of the division of bac­ teriology and virology, and deputy director of the National Institute for Medical Research in London. When researchers are faced with a seemingly new phenomenon, ex­ planations are easy to come by. These explanations fall into two broad categories: the phenomenon in question is either due to something or to the lack of something. I apologize for the primitive way in which I ex­ press this, but I am going to give three examples, scattered over 100 years, of what I mean. First example: in 1880 the great French microbiologist Louis Pas­ teur was involved in work on chicken cholera. He was struck by the following observation: if a suitable chicken broth was inoculated with the bacterium, the organism grew profusely and the liquid became tur­ bid. If he now freed the fluid, by sedimentation or filtration, from the bulk of the organisms and re-inoculated it with the same bacterium, no growth occurred. 
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