Ion Channels

Ion Channels edited by T. Narahashi.

In the past few years, the scientific community has witnessed rapid and significant progress in the study of ion channels. Technological advance­ ment in biophysics, molecular biology, and immunology has been greatly accelerated, making it possible to conduct experiments that were deemed very diffic...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Narahashi, T. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer US : Imprint: Springer, 1990.
Edition:1st ed. 1990.
Series:Ion Channels
Springer eBook Collection.
Subjects:
Animal physiology.
Biophysics.
Biological physics.
Neurosciences.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 Channel Protein Engineering: An Approach to the Identification of Molecular Determinants of Function in Voltage-Gated and Ligand-Regulated Channel Proteins
  • 1. The Question
  • 2. The Approach
  • 3. The Voltage-Sensitive Sodium Channel
  • 4. The Nicotinic Acetylcholine Receptor
  • 5. Other Channel Proteins
  • 6. Concluding Remarks
  • 7. References
  • 2 The Role of Nonprotein Domains in the Function and Synthesis of Voltage-Gated Sodium Channels
  • 1. Introduction
  • 2. Purification and Physicochemical Characterization of Sodium Channels from Electric Organ
  • 3. Possible Roles of Nonprotein Domains in the Function of Sodium Channels
  • 4. Functional Consequences of Manipulating Nonprotein Domains in Purified Sodium Channels
  • 5. Acquisition of Nonprotein Domains during Biosynthesis
  • 6. Conclusion
  • 7. References
  • 3 The Gating Current of the Node of Ranvier
  • 1. Introduction
  • 2. The Charge—Voltage Relation
  • 3. The Time Constants ?on and ?off
  • 4. Charge Immobilization
  • 5. The Chemical Nature of the Gating Particles
  • 6. The Effect of Local Anesthetics
  • 7. Comparison between Gating Current and Sodium Current
  • 8. References
  • 4 The Inactivation of Sodium Channels in the Node of Ranvier and Its Chemical Modification
  • 1. Introduction
  • 2. Inactivation
  • 3. Modifiers of Both Activation and Inactivation
  • 4. Modifiers of Inactivation Alone
  • 5. Modifiers as Chemical Probes of Channel Protein
  • 6. Summary and Conclusions
  • 7. References
  • 5 ATP-Activated Channels in Excitable Cells
  • 1. Introduction
  • 2. A Family of Nonselective Cation Channels
  • 3. ATP-Activated Potassium Channels in Atrial Cells
  • 4. Modulation of Voltage-Dependent and Other Channels
  • 5. Summary and Conclusions
  • 6. References
  • 6 Regulation of the ATP-Sensitive Potassium Channel
  • 1. Introduction
  • 2. Regulation of the ATP-Sensitive K+ Channel by Nucleotides
  • 3. The ATP-Sensitive K+ Channel Is the Receptor for Sulfonylureas
  • 4. Phosphorylation of the ATP-Sensitive K+ Channel by Kinase C
  • 5. Regulation of the ATP-Sensitive K+ Channel in ? Cells by Hormonal Peptides
  • 6. Cardiac ATP-Sensitive K+ Channels Are Activated by Cromakalim (BRL 34915)
  • 7. What Are ATP-Sensitive K+ Channels Regulating?
  • 8. References
  • 7 Analytical Diffusion Models for Membrane Channels
  • 1. Introduction
  • 2. Derivation of One-Ion Channel Diffusion Theory
  • 3. Channel States and Transition Rates
  • 4. Electrodiffusion Interpretation of Transition Rates
  • 5. Transition Rates as Mean First Passage Times
  • 6. Standard Results
  • 7. Discussion
  • 8. Appendix: Comparison of One-Ion Diffusion Model with Traditional Chemical Kinetics
  • 9. Symbols
  • 10. References.

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