Anticancer Drug Development Guide Preclinical Screening, Clinical Trials, and Approval

Anticancer Drug Development Guide Preclinical Screening, Clinical Trials, and Approval / edited by Beverly A. Teicher, Paul A. Andrews.

In this thoroughly updated and expanded second edition of Beverly Teicher's widely used classic survey, Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, leading cancer researchers from pharmaceutical companies, government laboratories, and academia provid...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Teicher, Beverly A. (Editor), Andrews, Paul A. (Editor)
Format: eBook
Language:English
Published: Totowa, NJ : Humana Press : Imprint: Humana, 2004.
Edition:1st ed. 2004.
Series:Cancer Drug Discovery and Development,
Springer eBook Collection.
Subjects:
Oncology  .
Pharmacology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • I: In Vitro Methods
  • 1 High-Volume Screening
  • 2 High-Throughput Screening in Industry
  • 3 The NCI Human Tumor Cell Line (60-Cell) Screen: Concept, Implementation, and Applications
  • 4 Human Tumor Screening
  • II: In Vivo Methods
  • 5 Murine L1210 and P388 Leukemias
  • 6 In Vivo Methods for Screening and Preclinical Testing: Use of Rodent Solid Tumors for Drug Discovery
  • 7 Human Tumor Xenograft Models in NCI Drug Development
  • 8 NCI Specialized Procedures in Preclinical Drug Evaluations
  • 9 Patient-Like Orthotopic Metastatic Models of Human Cancer
  • 10 Preclinical Models for Combination Therapy
  • 11 Models for Biomarkers and Minimal Residual Tumor
  • 12 Spontaneously Occurring Tumors in Companion Animals As Models for Drug Development
  • III: Nonclinical Testing to Support Human Trials
  • 13 Nonclinical Testing: From Theory to Practice
  • 14 Nonclinical Testing for Oncology Drug Products
  • 15 Nonclinical Testing for Oncology Biologic Products
  • IV: Clinical Testing
  • 16 Working With the National Cancer Institute
  • 17 Phase I Trial Design and Methodology for Anticancer Drugs
  • 18 Phase II Trials: Conventional Design and Novel Strategies in the Era of Targeted Therapies
  • 19 Drug Development in Europe: The Academic Perspective
  • 20 The Phase III Clinical Cancer Trial
  • 21 Assessing Tumor-Related Symptoms and Health-Related Quality of Life in Cancer Clinical Trials: A Regulatory Perspective
  • 22 The Role of the Oncology Drug Advisory Committee in the FDA Review Process for Oncologic Products
  • 23 FDA Role in Cancer Drug Development and Requirements for Approval.

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