| Summary: | The concept of this manuscript is to incorporate the basic knowledge which is necessary for the practical use of central analgesics and their antagonists in a concise and understandable form. With this concept in mind the enormous advances of the last decade with regard to the mode of action of opioids are covered. The manuscript is not intended to be a scientific textbook; rather, it is meant to be an introductory reference book about opioids and their antagonists, and about their pros and cons with regard to the various specialities where opioids are used for the alleviation of pain. Because of its brevity there is no question of its being complete. Where new information necessitates extended explanation, there is a detailed discussion. In other cases value has been placed on conciseness. The author is grateful for any advice, corrections and suggestions. The work of William A. Coleman, who prepared the translation, is greatly appre ciated. Dusseldorf, January 1987 EnnoFreye Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V The Use of Opioids During Anaesthesia and Their Importance in Clinical Application ................................... 1 Classical Potentiated Anaesthesia ............................ 3 Relaxation Anaesthesia .................................. 3 Neurolepsis .......................................... 4 Neuroleptanaesthesia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Sequential Anaesthesia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Synaptangalgesia ...................................... 8 Balanced Anaesthesia ................................... 9 Techniquefor Balanced Anaesthesia Using Narcotic Analgesics ......... 10 The Mode of Action of Opioids . . . . . . . . . . . . . . . . . . . . . . . 15 . . . . . . . Specific Binding Sites for Opioids in the CNS ..................... 15 The Three Main Characteristics of Pain . . . . . . . . . . . . . . . . . .. . . . 19 . . .
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