Cytochrome P450 Structure, Mechanism, and Biochemistry

Cytochrome P450 Structure, Mechanism, and Biochemistry / edited by Paul R. Ortiz de Montellano.

In the ten years that have elapsed since the first edition of this book went to press, the cytochrome P450 field has completed the transition to a discipline in which structure and mechanism, even regulation and biological function, are dealt with in molecular terms. The twin forces that have propel...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Ortiz de Montellano, Paul R. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer US : Imprint: Springer, 1995.
Edition:2nd ed. 1995.
Series:Springer eBook Collection.
Subjects:
Pharmacology.
Biochemistry.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • I. Model Systems
  • 1. Models and Mechanisms of Cytochrome P450 Action
  • 2. Comparison of the Peroxidase Activity of Hemoproteins and Cytochrome P450
  • II. Structurally Defined Bacterial Enzymes
  • 3. Twenty-five Years of P450camResearch: Mechanistic Insights into Oxygenase Catalysis
  • 4. Structural Studies on Prokaryotic Cytochromes P450
  • 5. Bacterial P450s: Structural Similarities and Functional Differences
  • III. Structures and Mechanisms of Membrane-Bound P450 Enzymes
  • 6. Structures of Eukaryotic Cytochrome P450 Enzymes
  • 7. NADPH Cytochrome P450 Reductase and Its Structural and Functional Domains
  • 8. Oxygen Activation and Reactivity
  • 9. Inhibition of Cytochrome P450 Enzymes
  • IV Regulatory Mechanisms and Physiological Roles of Cytochrome P450
  • 10. Induction of Cytochrome P450 Enzymes that Metabolize Xenobiotics
  • 11. Hormonal Regulation of Liver Cytochrome P450 Enzymes
  • 12. Regulation of Steroidogenic and Related P450s
  • 13. Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids
  • 14. Human Cytochrome P450 Enzymes
  • 15. Heme—Thiolate Proteins Different from Cytochromes P450 Catalyzing Monooxygenations
  • Appendices
  • A. Cytochrome P450 Nomenclature and Alignment of Selected Sequences
  • B. Rat and Human Liver Cytochromes P450: Substrate and Inhibitor Specificities and Functional Markers.

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