Dopamine in the CNS I

Dopamine in the CNS I edited by Gaetano Di Chiara.

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Di Chiara, Gaetano (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2002.
Edition:1st ed. 2002.
Series:Handbook of Experimental Pharmacology, 154 / 1
Springer eBook Collection.
Subjects:
Neurosciences.
Pharmacology.
Biochemistry.
Cell biology.
Neurology .
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 Brain Dopamine: A Historical Perspective
  • A. Introduction
  • B. The First Half-Century: 1910–1959
  • C. &“The Great Brain Serotonin-Catecholamine Debate”
  • D. Striatal Dopamine, Parkinson‚s Disease and Dopamine Replacement
  • E. Dopamine Pathways
  • F. Experimental Models of Parkinson‚s Disease
  • G. Dopamine Toxins
  • H. Dopamine Uptake
  • I. Physiology and Pathophysiology of Brain Dopamine
  • J. Specific Dopamine Receptors
  • K. Direct-Acting Dopamine Agonists
  • L. Dopamine and Striatal Neurotransmitter Interactions
  • M. Dopamine in Psychiatry
  • N. Concluding Remark
  • Abbreviations
  • References
  • 2 Birth of Dopamine: A Cinderella Saga
  • A. Introduction
  • B. Brodie‚s Breakthrough Discovery, Focusing on Serotonin
  • C. Catecholamines Entering the Scene
  • D. Discovery of Dopamine
  • E. Facing Rejection by Leaders in the Field
  • F. New Evidence for Monoaminergic Neurotransmission
  • G. A Paradigm Shift: Chemical Transmission in the Brain and Emerging Synaptology
  • H. &“Awakenings&”
  • I. Mode of Action of Antipsychotic Agents
  • J. Dopamine, the Reward System, and Drug Dependence
  • K. Autoreceptors: Discovery and Therapeutic Implications
  • L. Concluding Remarks
  • References
  • 3 The Place of the Dopamine Neurons Within the Organization of the Forebrain
  • A. Introduction
  • B. The Midbrain and Striatal Circuitry
  • C. Connections Between the Midbrain and Cortex
  • D. The Amygdala and Other Forebrain Projections
  • E. Functional Modulation and Integration Through Dopamine Forebrain Pathways
  • References
  • 4 Synaptology of Dopamine Neurons
  • A. Introduction
  • B. Methods for Ultrastructural Labeling of DA Axons
  • C. Regional Observations of DA Synaptology
  • D. Discussion
  • Abbreviations
  • References
  • 5 D1-Like Dopamine Receptors: Molecular Biology and Pharmacology
  • A. Introduction
  • B. Molecular Biology of D1-Like Receptors
  • C. D1-Like Receptor Pharmacology
  • D. Molecular Aspects of Functional Coupling and Signal Transduction for D1-Like Receptors
  • E. Distribution of D1-Like Receptors
  • F. Pharmacology of D1-Like Receptor-Mediated Function: Behaviour and D1-Like:D2-Like Interactions
  • G. Are There Additional D1-Like Receptor Subtypes?
  • H. Conclusions
  • References
  • 6 Understanding the Function of the Dopamine D2 Receptor: A Knockout Animal Approach
  • A. Introduction
  • B. Transcriptional Regulation of the Dopamine D2 Receptor
  • C. Dopamine D2 Receptor Signal Transduction
  • D. D2 Receptor Function In Vivo
  • E. D2 Receptor‚s Role as an Autoreceptor
  • F. D2 Receptor Signaling in Physiology
  • G. Neuronal Protective Pathways via the D2 Receptor
  • H. Antiproliferative Role of Dopamine in the Pituitary
  • I. Genetic Association of the D2 Receptor with Disease
  • J. Distinct Functions of the Dopamine D2 Receptor Isoforms
  • K. Conclusion
  • References
  • 7 The Dopamine D3 Receptor and Its Implication in Neuropsychiatric Disorders and Their Treatments
  • A. Introduction
  • B. Intracellular Signaling of the D3 Receptor
  • C. Pre- and Postsynaptic Localizations of the D3 Receptor in the Brain
  • D. Coexisting D1 and D3 Receptors in Ventral Striatum Mediate Both Synergistic and Opposite Responses
  • E. D1/D3 Receptor Interplay in the Induction and Expression of Behavioral Sensitization: Role of Brain-Derived Neurotrophic Factor
  • F. D3 Receptor-Selective Pharmacological Agents
  • G. The D3 Receptor and Schizophrenia
  • H. The D3 Receptor and Drug Addiction
  • I. The D3 Receptor and Depression
  • J. Conclusions
  • References
  • 8 Dopamine D4 Receptors: Molecular Biology and Pharmacology
  • A. The Dopamine D4 Receptor
  • B. The Multiple Human D4 Receptors
  • C. The D4 Receptor Involvement in Schizophrenia
  • D. Conclusions
  • References
  • 9 Signal Transduction by Dopamine D1 Receptors
  • A. Historical Perspective
  • B. GTP-Binding Proteins Associated with D1-Family Receptors
  • C. Adenylyl Cyclases and Phosphodiesterases in the Striatum
  • D. cAMP-Dependent Protein Kinase
  • E. cAMP-Activated Phosphorylation Pathways
  • F. The Role of Protein Phosphatase 1 in the Action of D1 Receptors
  • G. DARPP-32
  • H. Other Actions of cAMP
  • I. Concluding Remarks
  • References
  • 10 The Dopamine Transporter: Molecular Biology, Pharmacology and Genetics
  • A. Introduction
  • B. Molecular Biology
  • C. Distribution of the Dopamine Transporter
  • D. Pharmacology
  • E. Genetics Related to the Dopamine Transporter
  • Abbreviations
  • References
  • 11 Cellular Actions of Dopamine
  • A. Introduction
  • B. DA Receptor Expression in Neostriatal Neurons
  • C. Dopaminergic Modulation of Intrinsic Properties of Neostriatal Neurons
  • D. D1 Receptor Modulation of Synaptic Transmission and Repetitive Activity in Medium Spiny Neurons
  • E. Modulation of Synaptic Transmission by D2-Like Receptors
  • F. Dopaminergic Regulation of Corticostriatal Synaptic Plasticity
  • G. Summary and Conclusions
  • References
  • 12 Dopamine and Gene Expression
  • A. Introduction
  • B. Dopamine Signaling to the Nucleus
  • C. Acute Effects of Dopamine on Gene Expression
  • D. Chronic Effects of Dopamine on Gene Expression
  • References.

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