Ion Channels Volume 1

Ion Channels Volume 1 / edited by T. Narahashi.

A wealth of information has been accumulated about the function of ion channels of excitable cells since the extensive and pioneering voltage clamp studies by Hodgkin, Huxley, and Katz 36 years ago. The study of ion chan­ nels has now reached a stage at which a quantum jump in progress is antici­ pa...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Narahashi, T. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer US : Imprint: Springer, 1988.
Edition:1st ed. 1988.
Series:Ion Channels ; 1
Springer eBook Collection.
Subjects:
Animal physiology.
Biophysics.
Biological physics.
Neurosciences.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 Fluorescence Spectroscopy to Probe the Structure and Cellular Dynamics of Ion Channels
  • 1. Introduction
  • 2. Methods, Principles, and Utility of Fluorescence Spectroscopy
  • 3. Selection, Design, and Utilization of Ion Channel Probes
  • 4. Fluorescence Spectroscopy of the Voltage-Dependent Na + Channel
  • 5. Cellular Mapping of Na+ Channels in Excitable Tissues
  • 6. Conclusion
  • 7. References
  • 2 M Currents
  • 1. Prologue
  • 2. M Current
  • 3. M-Current Kinetics
  • 4. Physiological Function
  • 5. Pharmacology of M Current
  • 6. Synaptic Inhibition of M Current
  • 7. Future Work
  • 8. References
  • 3 Macromolecular Sites for Specific Neurotoxins and Drugs on Chemosensitive Synapses and Electrical Excitation in Biological Membranes
  • 1. Introduction
  • 2. Voltage and Patch Clamping
  • 3. Impact of Neurotoxins in Molecular Pharmacology
  • 4. The Histrionicotoxins
  • 5. Summary
  • 6. References
  • 4 Developmental Changes in Acetylcholine Receptor Channel Properties of Vertebrate Skeletal Muscle
  • 1. Introduction
  • 2. Materials and Methods
  • 3. Results
  • 4. Discussion
  • 5. Postscript
  • 6. References
  • 5 Intracellular ATP and Cardiac Membrane Currents
  • 1. Introduction
  • 2. Techniques for the Single Cardiac Cell
  • 3. Whole-Cell Current and Intracellular ATP Level
  • 4. ATP-Sensitive K Channel
  • 5. Effects of ATP on Other K Channels
  • 6. Conclusion
  • 7. References
  • 6 Calcium Antagonist Receptors
  • 1. Introduction
  • 2. Radioreceptor Binding Studies
  • 3. Atypical Actions of Calcium Antagonists
  • 4. The Relation of Calcium Antagonist Receptors to Voltage-Sensitive Calcium Channels
  • 5. Future Developments in Calcium Antagonist Receptors
  • 6. References
  • 7 The Amiloride-Blockable Sodium Channel of Epithelial Tissue
  • 1. Introduction
  • 2. Na+ Uptake at the Apical Membrane
  • 3. A6 Cells as a Model for Kidney Distal Tubule
  • 4. Single Na + Channel Activity
  • 5. A Model for the Regulation of Apical Na+ Permeability
  • 6. Future Work
  • 7. References
  • 8 Ionic Channels in Ocular Epithelia
  • 1. Introduction
  • 2. Low-Noise Methods and Glass Considerations
  • 3. General Approach to Channel Identification
  • 4. Selectivity
  • 5. Current-Voltage Relations
  • 6. Kinetics of Gating
  • 7. Characterization of Blockers
  • 8. Channel Types Observed in Ocular Epithelia
  • 9. References.

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