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|a 10.1007/978-1-4615-6347-1
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|a Bulpitt, Christopher J.
|e author.
|4 aut
|4 http://id.loc.gov/vocabulary/relators/aut
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| 245 |
1 |
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|a Randomised Controlled Clinical Trials
|h [electronic resource] /
|c by Christopher J. Bulpitt.
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| 250 |
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|a 2nd ed. 1996.
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| 264 |
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1 |
|a New York, NY :
|b Springer US :
|b Imprint: Springer,
|c 1996.
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| 300 |
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|a IX, 437 p.
|b online resource.
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|b txt
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|a 1. Introduction -- 2. The history of controlled trials -- 3. Ethical considerations -- 4. The objectives of a randomised controlled trial -- 5. Different trial designs -- 6. How many subjects are required for a trial? -- 7. How to ensure that the results are free of bias -- 8. Writing the protocol -- 9. Recruitment of subjects -- 10. Information to be collected during a trial -- 11. The conduct of the trial — Good Clinical Practice -- 12. Stopping rules for trials -- 13. The variability and validity of results -- 14. Analysis of the results, subgroup and meta-analysis -- 15. The evaluation of subjective well-being and measurement of quality of life -- 16. The detection of adverse drug reactions -- 17. Measurement of the benefit; risk comparison, cost-effectiveness and cost-utility -- 18. Early trials on new drugs -- 19. Failure to accept the results of randomised controlled trials -- 20. The advantages and disadvantages of randomised controlled trials -- References.
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| 520 |
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|a After 13 years there are new areas to discuss and more recent trials to be included. Good clinical practice; evaluation of quality of life; measurement of the benefit:risk comparison; determination of cost- effectiveness and cost utility; stopping rules for trials; meta-analysis and subgroup analysis are all new sections. The references are expanded from 305 to 512 and include the recent advances in trial design, such as the n-of-1 trials and megatrials, and up-to-date examples to illustrate the points made in the 20 chapters.
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| 590 |
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|a Loaded electronically.
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| 590 |
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|a Electronic access restricted to members of the Holy Cross Community.
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| 650 |
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|a Medicinal chemistry.
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| 650 |
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|a Medical laws and legislation.
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| 650 |
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|a Health informatics.
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| 690 |
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|a Electronic resources (E-books)
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| 710 |
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