Proteasome Inhibitors in Cancer Therapy

Proteasome Inhibitors in Cancer Therapy edited by Julian Adams.

Immediately upon the discovery some ten years ago that inhibition of the proteasome in cultured cells, mostly of tumor origin, caused the programmed cell death machinery to ramp up, it became imperative to investigate proteasome inhibition as a possible treatment for human cancers. In Proteasome Inh...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Adams, Julian (Editor)
Format: eBook
Language:English
Published: Totowa, NJ : Humana Press : Imprint: Humana, 2004.
Edition:1st ed. 2004.
Series:Cancer Drug Discovery and Development,
Springer eBook Collection.
Subjects:
Oncology  .
Cancer research.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • I Cancer Drug Development
  • 1 Cancer Drug Development: Challenges in a Competitive Market
  • II Chemistry and Cell Biology of the Proteasome
  • 2 Introduction to the Proteasome and Its Inhibitors: Biochemistry and Cell Biology
  • 3 Structures of the Yeast Proteasome Core Particle in Complex with Inhibitors
  • 4 Natural Product and Synthetic Proteasome Inhibitors
  • 5 Other Proteasome Inhibitors
  • 6 The Proteasome in Cell-Cycle Regulation
  • 7 Proteasome Inhibition and Apoptosis
  • 8 The Proteasome and the COMPARE Algorithm
  • III Rationale for Proteasome Inhibitors in Cancer
  • 9 The Proteasome in Cancer Biology and Therapy
  • 10 Radiosensitization and Proteasome Inhibition
  • 11 Proteasome-Dependent Regulation of NF-?B Activation: Molecular Targeting of Chemotherapy Resistance
  • 12 Bortezomib with Taxanes
  • 13 Proteasome Inhibitor Therapy in a Brain Tumor Model
  • 14 Anthracyclines and Bortezomib
  • 15 TNF-Related Apoptosis-Inducing Ligand (TRAIL): Combination with Proteasome Inhibition For Anticancer Therapy?
  • 16 Rationale for Combining the Proteasome Inhibitor Bortezomib with Cisplatin
  • 17 The Effects of the HIV-1 Protease Inhibitor Ritonavir on Proteasome Activity and Antigen Presentation
  • 18 Function(s) of the Ubiquitin—Proteasome System in Retrovirus Budding
  • IV Clinical Trials
  • 19 Preclinical Development of Bortezomib (VELCADE™): Rationale for Clinical Studies
  • 20 Phase I Trials: Bortezomib Alone and in Combination With Standard Chemotherapies
  • 21 Clinical Molecular Diagnostics for Proteasome Inhibitors in Cancer Therapy
  • 22 Phase II Trials of Bortezomib for the Treatment of Multiple Myeloma.

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