Inhalation Toxicology The Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment

Inhalation Toxicology The Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment / edited by Ulrich Mohr.

The International Life Sciences Institute (ILSI), a nonprofit, public foundation, was established in 1978 to advance the sciences of nutrition, toxicology, and food safety. ILSI promotes the resolution of health and safety issues in these areas by sponsoring research, conferences, publications, and...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Mohr, Ulrich (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1988.
Edition:1st ed. 1988.
Series:ILSI Monographs
Springer eBook Collection.
Subjects:
Pathology.
Respiratory organs—Diseases.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • I. Approaches to Assessing the Toxicity of Airborne Toxicants
  • 1. Standard-Setting as an Integrative Exercise: Alchemy, Juggling, or Science?
  • 2. Species Differences in Inhalation Toxicology: Variations in Exposure-Dose Relationships and Macrophage Function
  • 3. Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, and Morphology
  • 4. Comparative Metabolic Basis for the Disposition and Toxic Effects of Inhaled Materials
  • II. Methodological Issues in Designing and Conducting Studies with Laboratory Animals
  • 5. Exposure Facilities and Aerosol Generation and Characterization for Inhalation Experiments
  • 6. Different Methods Used in Acute and Subchronic Inhalation Studies of Potential Lung Irritants, with Particular Attention to Lung Function Measurements
  • 7. Chronic Inhalation Toxicity Studies: Protocols and Pitfalls
  • 8. Carcinogenicity Protocols
  • III. Interpretation of Toxicokinetic Studies with Airborne Toxicants
  • 9. Interspecies Dosimetry of Reactive Gases
  • 10. Behavior of Inspired Aerosol Boli in Humans
  • 11. Respiratory Tract Clearance of Particles and Substances Dissociated from Particles
  • IV. Interpretation of Results Using Laboratory Animals
  • 12. Interpretation of Early Lesions in the Mouse Lung: Fibrogenesis and Tbmorigenesis
  • 13. Relevance to Humans of Experimentally Induced Pulmonary Tumors in Rats and Hamsters
  • 14. Experimentally Induced Emphysema and Long-Term Nitrogen Dioxide Inhalation
  • 15. Comparison of Respiratory Function Responses of Laboratory Animals and Humans
  • V. Risk Assessment of Airborne Toxicants
  • 16. Population Studies in Risk Assessment: Strengths and Weaknesses
  • 17. Human Clinical Exposure Studies: Body Box or Pandora’s Box?
  • 18. Occupational Exposure Standards in Europe: History, Present Status, and Future Trends
  • 19. Current Approaches for Determining Workplace Exposure Limits in the USA.

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