Neuropilin From Nervous System to Vascular and Tumor Biology

Neuropilin From Nervous System to Vascular and Tumor Biology / edited by Dominique Bagnard.

Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica­ tion of several families of adhesion molecules, well con...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Bagnard, Dominique (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer US : Imprint: Springer, 2002.
Edition:1st ed. 2002.
Series:Advances in Experimental Medicine and Biology, 515
Springer eBook Collection.
Subjects:
Neurosciences.
Cardiology.
Internal medicine.
Cancer research.
Veterinary medicine.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1. From the Discovery of Neuropilin to the Determination of Its Adhesion Sites
  • Summary
  • Identification of Monoclonal Antibodies that RecognizeXenopusNRP and Plex
  • Molecular Cloning and Structure of NRP
  • Expression of NRP in the Nervous System
  • Cell Adhesion Properties of NRP1
  • Conclusion
  • 2. Neuropilins as Semaphorin Receptors: In Vivo Functions in Neuronal Cell Migration and Axon Guidance
  • Summary
  • Identification and Characterization of Neuropilins as Semaphorin Receptors
  • In vivo Functions of Neuropilins in Nervous System Wiring During Development
  • Conclusion
  • 3. The Role of Neuropilin in Vascular and Tumor Biology
  • Summary
  • Neuropilin Expression in Endothelial Cells
  • Regulation of Neuropilin Expression in Blood Vessels
  • Neuropilin and Angiogenesis
  • Tumor Cell Neuropilin
  • Vascular Injury
  • Perspectives and Future Directions
  • 4. Neuropilin-1 In the Immune System
  • Summary
  • Neuropilin-1 is Expressed by Dendritic Cells and Resting T cells
  • T Cell-Dendritic Cell Interaction Induces Neuropilin-1 Polarization in T Cells
  • Neuropilin-1 Promotes Cell-Cell Interactions
  • Neuropilin-1 Mediates the Dendritic Cells-Induced Proliferation of Resting T Cells
  • Discussion
  • 5. Structural and Functional Relation of Neuropilins
  • Summary
  • Primary Structure and Genomic Structure of Neuropilin
  • Binding Properties of NRP Domains
  • Neuropilin-1 Interacting Protein Binds to the Carboxyl Terminus of NRP1
  • Additional Receptor Required for Signal Transduction
  • Concluding Remarks
  • 6. The Function of Neuropilin/Plexin Complexes
  • Summary
  • Neuropilins Form the Ligand-Binding Subunit of the Sema3A Receptors
  • Plexins Act as the Signal-Transducing Subunit of Semaphorin Receptors
  • Plexins are Essential Components of the Sema3A Receptor
  • The Role of GTPases for Signal Transduction by Plexins
  • Open Questions
  • 7. The Interaction of Neuropilin-1 and Neuropilin-2 with Tyrosine-Kinase Receptors for VEGF
  • Summary
  • The Mechanism by Which NRPI Affects VEGF Induced Signaling by the VEGFR2 Receptor
  • The Interaction of Neuropilins with VEGFRI
  • Conclusions
  • 8. The Function of Neuropilin/Ll Complex
  • Summary
  • L1 and NRP1 Associate Through Their Extracellular Domains
  • L1/NRP1 Complex Formation Regulates Axonal Responsiveness to a Secreted Semaphorin
  • L1/NRP1 Complex Specifies Growth Cone Responses to Sema3A
  • Soluble L1 Modulates Axonal Responsiveness to Sema3A
  • Other Putative Functions Served by L1/NRP1 Complex Formation
  • Pivotal Molecules in Axon Guidance
  • 9. Neuropilin and Its Ligands in Normal Lung and Cancer
  • Summary
  • Neuropilin and Semaphorin in Normal Mice Lung Development
  • Neuropilins and Its Ligands in Human Lung Tumor
  • 10. Neuropilin and Class 3 Semaphorins in Nervous System Regeneration
  • Summary
  • General Features of CNS Regeneration
  • Semaphorin and Neuropilin in the Intact and Injured Olfactory System
  • Neuropilin Ligands are Expressed by the Fibroblast Component of Neural CNS Scars
  • Neuropilins are Expressed at the CNS Lesion Site
  • Neuropilin/Semaphorin Regulation in Rat Models for Status Epilepticus
  • General Aspects of PNS Regeneration
  • Neuropilin/Semaphorin Regulation in the Injured PNS
  • Conclusions.

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