The Influenza Viruses

The Influenza Viruses edited by Robert M. Krug.

Influenza virus is an important human pathogen, frequently causing widespread disease and a significant loss of life. Much has been learned about the structure of the virus, its genetic variation, its mode of gene expression and replication, and its interaction with the host immu­ nologic system. Th...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Krug, Robert M. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer US : Imprint: Springer, 1989.
Edition:1st ed. 1989.
Series:The Viruses
Springer eBook Collection.
Subjects:
Medical microbiology.
Plant science.
Botany.
Animal anatomy.
Microbial ecology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 Genes and Proteins of the Influenza Viruses
  • I. Introduction
  • II. RNA Segments 1, 2, and 3: The Three Polymerase-Associated Proteins Form a Complex to Transcribe RNA
  • III. RNA Segment 4: Synthesis, Structure, and Function of the Hemagglutinin
  • IV. RNA Segment 5: The Nucleocapsid Protein Forms the Structural Monomer Unit of the Ribonucleoprotein Particles
  • V. RNA Segment 6: The Neuraminidase
  • VI. RNA Segment 7 of Influenza A Virus: Structure and Synthesis of the Membrane Protein (M1) and an Integral Membrane Protein (M2) from Unspliced and Spliced mRNAs
  • VII. Influenza A Virus RNA Segment 8: Unspliced and Spliced mRNAs Encode Nonstructural Proteins NS1 and NS2
  • References
  • 2 Expression and Replication of the Influenza Virus Genome
  • I. Introduction
  • II. Viral mRNA Synthesis
  • III. Template RNA Synthesis
  • IV. Virion RNA Synthesis
  • V. Regulation of Viral Gene Expression in Infected Cells
  • VI. Interferon-Induced Mx Protein, a Specific Inhibitor of Influenza Virus Replication
  • VII. Regulated Splicing of the Viral NS1 and M1 mRNAs
  • VIII. Mechanisms for the Selective and Efficient Translation of Influenza Virus mRNAs
  • References
  • 3 Structure, Function, and Antigenicity of the Hemagglutinin of Influenza Virus
  • I. Introduction
  • II. Structure of Hemagglutinin
  • III. Antigenic Variation
  • IV. Receptor Binding
  • V. Fusion Properties of Hemagglutinin
  • VI. Conclusions
  • References
  • 4 Neuraminidase: Enzyme and Antigen
  • I. Introduction
  • II. Protein Structure
  • III. Antigenic Structure
  • IV. Summary
  • References
  • 5 Membrane Insertion and Intracellular Transport of Influenza Virus Glycoproteins
  • I. Introduction
  • II. Entry of Influenza Glycoproteins into the Exocytic Pathway
  • III. Protein Transport between the Endoplasmic Reticulum and the Golgi Apparatus
  • IV. Transport and Processing within the Golgi Apparatus
  • V. The Trans-Reticular Network
  • VI. Transport to the Cell Surface and Insertion into the Plasma Membrane
  • VII. Summary and Perspectives
  • References
  • 6 Structure of Defective-Interfering RNAs of Influenza Viruses and Their Role in Interference
  • I. Introduction
  • II. Nature of the DI Particle Genome
  • III. Generation of Influenza Virus Subgenomic/DI RNA
  • IV. Evolution of DI RNAs
  • V. Replication, Transcription, and Translation of DI RNAs
  • VI. Mechanism of Interference
  • VII. Possible Role of Influenza DI Particles in Modulating Viral Pathogenesis
  • VIII. Possible Role of DI Particles in Virus Evolution
  • IX. Summary and Conclusion
  • References
  • 7 Variation in Influenza Virus Genes: Epidemiological, Pathogenic, and Evolutionary Consequences
  • I. Introduction
  • II. Influenza Viruses in Humans
  • III. Homology of Influenza A, B, and C Viruses
  • IV. Variation in Influenza A Viruses
  • V. Variation in Influenza C Viruses
  • VI. Variation in Influenza B Viruses
  • VII. Genetic Basis of Pathogenicity
  • VIII. Comparison of Variation among Different RNA Viruses
  • References
  • 8 Specificity and Function of T Lymphocytes Induced by Influenza A Viruses
  • I. Introduction
  • II. General Properties of Antiviral T-Lymphocyte Responses
  • III. Specificity and Function of Anti-influenza Virus TH
  • IV. Specificity and Function of Anti-influenza Virus TC
  • V. Conclusions
  • References.

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