Autoimmunity and the Pathogenesis of Diabetes

Autoimmunity and the Pathogenesis of Diabetes edited by Fredda Ginsberg-Fellner, Robert C. McEvoy.

It has been a challenge for us to edit this volume of Endocrinology and Metabo­ lism: Progress in Research and Clinical Practice. The topic of the pathogenesis of insulin-dependent, type I diabetes mellitus is particularly appropriate for this series, since advances in this area have been made, to a...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Ginsberg-Fellner, Fredda (Editor), McEvoy, Robert C. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 1990.
Edition:1st ed. 1990.
Series:Endocrinology and Metabolism, Progress in Research and Clinical Practice, 4
Springer eBook Collection.
Subjects:
Endocrinology .
Allergy.
Immunology.
Metabolic diseases.
Virology.
Human genetics.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1. The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present
  • Autoimmunity
  • The Concept of IDDM as an Autoimmune Disease
  • The Association Between IDDM and HLA
  • Etiologic Factors with Implications for the Pathogenesis of IDDM
  • The Autoantigen in IDDM
  • Presentation of Autoantigen
  • Autoantigen Recognition in IDDM
  • The Effector Phase in IDDM
  • Conclusion
  • 2. Immunogenetics and the Pathogenesis of Insulin-Dependent Diabetes Mellitus
  • Genetic Background
  • Environmental Factors
  • Speculations on the Mechanism of IDDM Pathogenesis
  • 3. Association of Insulin-Dependent Diabetes Mellitus and Other Autoimmune Diseases
  • IDDM and Thyroid Autoimmunity
  • Other Endocrinopathies Associated with Type 1 Diabetes Mellitus
  • How Does Autoimmune Disease Develop?
  • Can Autoantibodies Affect More Than One Gland? Are They Mono- or Polyclonal?
  • Summary and Conclusions
  • 4. The Humoral Anti-Islet Immune Response: Cytoplasmic Islet-Cell Antibodies: Technical Aspects and Clinical Applications
  • Assays for ICA Determination
  • Approaching Standardization of the Cytoplasmic ICA Test
  • Clinical Application of the ICA Test
  • Synopsis, Recommendations, and Conclusions
  • 5. The Humoral Anti-Islet Response: Biochemical Characterization
  • Autoantigens Detected in Human Islets
  • Autoantigens May Define Disease Specificity in Human Autoimmunity
  • Western Blotting Analysis of Islet Autoantigens
  • Analyzing Circulating Immune Complexes in Diabetes
  • Summary
  • 6. The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens
  • What Are Gangliosides?
  • Immunochemical Characterization of Monoclonal Antibody-Defined, Islet-Cell Antigens
  • Immunochemical Properties of the Autoantigen(s) of Pancreatic Islets
  • Extraction and Partial Purification of the ICA Glycolipid Antigen
  • Glycolipid Antigens in Animal Models of Type I Diabetes
  • Multiplicity of Antigens in Humoral Autoimmunity of Type I Diabetes
  • Monoclonal Antibody-Defined, Islet-Cell Glycolipid Antigens
  • Physiological Roles of Islet-Cell Gangliosides
  • Antibodies to Glycolipids in Diseases Other than Type I Diabetes Mellitus
  • Immunogenicity of Glycolipids
  • T-Cell Reactivity to Glycolipid Antigens
  • Final Comments
  • 7. Insulin Autoantibodies
  • 8. Cell-Mediated Anti-Islet—Cell Immune Response: Clinical Experience and Lessons from Animal Models
  • Cell-Mediated, Anti-Beta—Cell Autoimmunity in Human Diabetes
  • Diabetes Induced by Multiple, Subdiabetogenic Doses of Streptozotocin
  • Diabetes in the Bio-Breeding Rat
  • Diabetes in Nonobese Diabetic Mice
  • Summary and Conclusions
  • 9. The Pathogenesis of Immunologically Mediated Diabetes
  • Mechanism of the Disease Process
  • Disease Recurrence Model
  • Disease Recurrence in Islet Grafts is CD4 T-Cell Dependent
  • Free Radical Involvement in the Disease Process
  • Disease Recurrence in the Grafted Tissue: A Summary
  • Lessons from Fetal Pancreas Transplantation
  • Effect of Cyclosporine on Disease Recurrence
  • 10. Viral Pathogenesis of Insulin-Dependent Diabetes Mellitus
  • Direct Cytolytic Viral Infection of Beta-Cells
  • Association of Virus Infection with Autoimmune IDDM
  • Persistent Infection of Pancreatic Beta-Cells and Mild Hyperglycemia
  • Conclusion
  • 11. Immune Intervention in Diabetes: State of the Art and Future Directions
  • Experimental Immunotherapy in IDDM of Recent Onset
  • Open Studies of Immunomodulatory Therapies in IDDM
  • Randomized Control Trials of the Effects of Cyclosporin in IDDM
  • Efficacy and Safety of Immunosuppression in Remission Induction in IDDM
  • Timing of Immunomodulatory Interventions in IDDM
  • IDDM in Remission: Endocrine Metabolic Status and Its Possible Implications
  • Strategies for Continuing Studies of Immunotherapy in IDDM
  • Summary and Conclusions.

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