Advances in Prostaglandin and Leukotriene Research Basic Science and New Clinical Applications / edited by Bengt Samuelsson, Rodolfo Paoletti, Giancarlo Folco, E. Granström, S. Nicosia.

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Bibliographic Details
Corporate Author:	SpringerLink (Online service)
Other Authors:	Samuelsson, Bengt (Editor), Paoletti, Rodolfo (Editor), Folco, Giancarlo (Editor), Granström, E. (Editor), Nicosia, S. (Editor)
Format:	eBook
Language:	English
Published:	Dordrecht : Springer Netherlands : Imprint: Springer, 2001.
Edition:	1st ed. 2001.
Series:	Medical Science Symposia Series, 16 Springer eBook Collection.
Subjects:	Biochemistry. Human physiology. Pharmacology. Respiratory organs—Diseases. Electronic resources (E-books)
Online Access:	Click to view e-book
Holy Cross Note:	Loaded electronically. Electronic access restricted to members of the Holy Cross Community.

Table of Contents:

I Lipdxygenases and Leukotriene Biosynthesis
1. Phosphorylation and Activation of 5-Lipoxygenase by P38 Kinase-Activated MAPKAP Kinases
2. 5-Lipoxygenase and the Nucleus: Where, When, How, and Why?
3. Calcium Binding Site of 5-Lipoxygenase
4. Regulation of Cellular 5-Lipoxygenase Activity by Glutathione Peroxidases
5. Novel Aspects Related to Biosynthesis and Biological Actions of Hepoxilins: Interrelationship with Phospholipid Hydro-Peroxide Glutathione Peroxidase (PHGPx)
6. Transcriptional Regulation of the Human Leukotriene C4 Synthase Promoter
7. Localization and Translocation of Enzymes Involved in Leukotriene Biosynthesis
II Cyclooxygenases and Prostaglandin Biosynthesis
8. Regulation of COX-2 Expression in Fibroblasts, Osteoblasts, Mast Cells, and Macrophages
9. Antimicroinflammatory Lipid Signals from Vascular Cyclooxygenase-2: A Novel Mechanism for NSAID and N-3 PUFA Therapeutic Actions
10. Substrate Interactions in the Cyclooxygenase-1 Active Site
11. Mutation of the Human Prostacyclin Synthase Gene
12. Structure and Function of Two Distinct Types of Prostaglandin D Synthase
13. Roles of Prostaglandin F Synthase
14. Differential Effects of Nitric Oxide on Cyclooxygenase 1 and 2 Activities in Cultured Cells
III Phospholipase A2
15. On the Functional Diversity of Secreted Phospholipases A2: Cloning of Novel Mammalian and HIV-1 Antiviral Properties
16. Regulation of Cytosolic Phospholipase A2 by Phosphorylation
IV Cytochrome P450 Archidonate Metabolites
17. Synthesis and Function of 20-Hydroxyeicosatetraenoic Acid in the Kidney
V Receptors
18. Altered Bronchodilation and Pulmonary Inflammation in Prostanoid EP2 Receptor Knockout Mice
19. Induction of Prostaglandin I2 Receptor in Murine Osteoblastic Cell
20. BLT2, a Second Leukotriene B4 Receptor
21. Upregulation of Cysteinyl-Leukotriene 1 Receptor Expression by Interleukin-5 in Human Leukocytes
22. Physiological and Pathophysiological Roles of Prostanoids; Lessons from Receptor-Knockout Mice for Clinical Applications
23. Multiple G-Protein Coupling of Chimeric Prostacyclin/Prostaglandin D2 Receptors
VI Eicosanoids and Neuroscience
24. An Unusual Nicotinic Acetylcholine Receptor Activates the 8-Lipoxygenase Pathway in Aplysia Neurons
VII Cardiovascular System
25. Neutrophil-Endothelial Cell Interaction: A Multidirectional Cross-Talk in Leukotriene Generation
26. Cyclooxygenase in the Lamb Ductus Arteriosus: Developmental Changes and Upregulation
27. Co-Localization of Prostacyclin (PGI2)-Synthase and Caveolin-1 in Endothelial Cells Underscores New Roles of PGI2 In Angiogenesis
VIII Respiratory System
28. Leukotriene C4 Synthase Gene Polymorphism in Severe Asthma
IX Inflammation
29. Anti-Inflammatory Levels of Aspirin and Salicylate Inhibit Integrin-Dependent Human Neutrophil Aggregation and PMN Influx in COX2- and NFkB(P105)- Knockout Mice
30. Antipyretic Action of Acetaminophen: Inhibition of the Cyclooxygenase Activity of Endothelial Cells Treated with IL-1
31. Leukotriene-Mediated Alteration of Endothelial Barrier Function
32. GI and Cardiovascular Profiles of New NSAIDs: Selective COX-2 Inhibitors and NO-NSAIDs
33. NO-Releasing NSAIDs Modulate Cytokine Secretion
34. Potent Inhibitory Effects of a NO-NSAID (Flurbiprofen Nitroxybutylester) on Bone Resorption in Vitro and in Vivo
X Cancer
35. Lipid Peroxidation and Cyclooxygenase-2 Activity in Human Hepatocellular Carcinoma Cell Lines with and without Multiple Drug Resistance: Correlation with Cell Growth
36. Pulmonary Prostacyclin Synthase Overexpression Improves Survival Following Butylated Hydroxytoluene Exposure
XI Isoprostanes
37. Reactive Products of the Isoprostane Pathway: Isoketals and Cyclopentenone A2/J2-Isoprostanes
38. Increased Isoprostane 8-epi-PGF2A in Statin-Induced Myopathy.

Advances in Prostaglandin and Leukotriene Research Basic Science and New Clinical Applications / edited by Bengt Samuelsson, Rodolfo Paoletti, Giancarlo Folco, E. Granström, S. Nicosia.

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