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|a 9781468452846
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|a 10.1007/978-1-4684-5284-6
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|a (DE-He213)978-1-4684-5284-6
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|a Platelet-Activating Factor and Related Lipid Mediators
|h [electronic resource] /
|c edited by F. Snyder.
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| 250 |
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|a 1st ed. 1987.
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|a New York, NY :
|b Springer US :
|b Imprint: Springer,
|c 1987.
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| 300 |
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|a XXII, 492 p. 57 illus., 1 illus. in color.
|b online resource.
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|b txt
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|a Introduction: Historical Aspects of Alkyl Lipids and Their BiologicallyActive Forms (Ether Lipids,Platelet-Activating Factor, andAntihypertensive Renal Lipids) -- I. Methodology and Chemistry -- 1. Chemical Synthesis and Mass Spectrometry of PAF -- 2. Chromatographic Analyses of Ether-Linked LipidsInvolved in PAF Metabolism -- II. Composition -- 3. Composition of Alkyl Ether-Linked Phospholipids in Mammalian Tissues -- III. Enzymes -- 4. Enzymatic Pathways for Platelet-Activating Factor, Related Alkyl Glycerolipids, their Precursors -- 5. Enzymatic Control of the Cellular Levels of Platelet-Activating Factor -- IV. Antagonists, Agonists, and Receptors -- 6. Platelet-Activating Factor Binding to Specific Cell Membrane Receptors -- 7. The Chemical and Biological Properties of PAF Agonists, Antagonists and Biosynthetic Inhibitors -- 8. Conformational Properties of the PAF-Acether Receptor on Platelets Based on Structure—Activity Studies -- V. Biochemical and Biological Aspects in Specific Cells and Tissues -- 9. Diversity of the Biochemical and Biological Behavior of Platelet-Activating Factor -- 10. Extracellular and Intracellular Activities of PAF -- 11. Interrelationships in the Metabolism of Platelet-Activating Factorand Arachidonate in Neutrophils -- 12. Platelet-Activating Factor: Mechanisms of Cellular Activation -- 13. The Role of Platelet-Activating Factor in Inflammation -- 14. The Production of Platelet-Activating Factor by Cultured Human Endothelial Cells: Regulation and Function -- 15. Bronchopulmonary Pharmacology of PAF-Acether -- 16. Platelet-Activating Factor: A Secretory Product from Phagocytes -- 17. Functions of PAF in Reproduction and Development: Involvement of PAF in Fetal Lung Maturation and Parturition -- 18. Effect of PAF on the Cardiovascular System -- 19. Biosynthesis and Release of PAF-Acether by Mouse Bone Marrow-Derived Mast Cells -- VI. Antitumor Analogs of PAF -- 20. Antineoplastic Actions of Ether Lipids Related to Platelet-Activating Factor.
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|a Platelet-activating factor (PAF) is the commonly used name for a group of potent biologically active, ether-linked phospholipids, the alkylacetylglycerophospho cholines. Following the identification of the chemical structure of P AF in 1979, much progress has been made in our understanding of these phospholipid medi ators. This is particularly true from the points of view of their molecular structural requirements for expression of biological activity, their biosynthesis and cata bolism, their diverse range of biological activities, evidence for their specific recep tors at the cell surface, the development of specific antagonists for use in receptor studies and for testing as potential anti-PAF drugs, and implications about their involvement in health and disease. Chapters in this book cover the current status of these general areas of PAF research. Although an enormous amount of information has been published about this interesting new type of phospholipid mediators, questions about their mechanism of action, regulatory controls, and the precise role and relative importance of P AF in specific diseases and physiological functions remain to be answered. Since the 1979 discovery, the PAF field has brought together scientists from a variety of different biomedical disciplines. The diversity of scientists now in PAF research is very apparent from the number of P AF publications appearing in a wide array of scientific journals, ranging from molecular biology to clinical medicine. Publications related to PAF continue to increase at an amazingly rapid rate, with the pace reminiscent of the period following the discovery of prostaglandins.
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|a Loaded electronically.
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|a Electronic access restricted to members of the Holy Cross Community.
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|a Biochemistry.
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|a Animal anatomy.
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|a Plant science.
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| 650 |
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|a Botany.
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| 690 |
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|a Electronic resources (E-books)
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| 700 |
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|a Snyder, F.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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