Intracranial Germ Cell Tumors

Intracranial Germ Cell Tumors edited by Yutaka Sawamura, Hiroki Shirato, Nicolas de Tribolet.

Intracranial germ cell tumors are a group of uncommon neoplasms of the central nervous system. The clinical features and natural history of these lesions are quite unique and variable. While intracranial germ cell tumors have been a fascination to neurooncologists for decades, the relatively small n...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Sawamura, Yutaka (Editor), Shirato, Hiroki (Editor), Tribolet, Nicolas de (Editor)
Format: eBook
Language:English
Published: Vienna : Springer Vienna : Imprint: Springer, 1998.
Edition:1st ed. 1998.
Series:Springer eBook Collection.
Subjects:
Neurosurgery.
Oncology  .
Pediatrics.
Radiotherapy.
Neurology .
Pathology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • I. Introduction
  • II. WHO histological classification of tumors of the central nervous system (CNS): germ cell tumors (GCTs)
  • III. Epidemiology of CNS GCTs
  • 1. Histological variation and incidence
  • 2. Racial and geographical factors
  • 3. Age factor
  • 4. Gender factor
  • 5. Anatomical factor
  • 6. Genetic factor
  • 7. Other factors
  • IV. Pathology
  • 1. General features of GCTs
  • 2. Germinoma
  • 3. Embryonal carcinoma
  • 4. Yolk sac tumor (Endodermal sinus tumor)
  • 5. Choriocarcinoma
  • 6. Teratomas
  • V. Immunobiology of tumor infiltrating lymphocytes (TIL) in germinomas
  • 1. Cell types of germinoma TIL
  • 2. The cause and role of immune cell infiltration in germinomas
  • 3. Cytotoxicity of TIL to tumor cells
  • 4. Conclusive remarks
  • VI. Genesis and genetics of intracranial germ cell tumors
  • 1. Clonal evolution model for tumorigenesis
  • 2. Oncogenes and tumor suppressor genes
  • 3. Problematic of ontogenesis of CNS and extracranial GCTs
  • 4. Oncogenesis of GCTs
  • VII. Clinical findings and diagnosis
  • 1. Neurological manifestations
  • Radiological diagnosis
  • 3. Endocrinological manifestations
  • 4. Ophthalmological manifestations
  • 5. Tumor markers
  • VIII. Prognosis of CNS GCTs
  • 1. Survival and recurrence after therapy
  • 2. Outcome of patients
  • IX. Overview of management
  • 1. Classification of CNS GCTs for management
  • 2. Diagnosis to select an appropriate treatment mode
  • 3. Overview of treatment
  • 4. Preliminary results of Japanese Cooperative Study
  • X. Surgical management
  • 1. Surgical strategy for germinomas
  • 2. Surgical approaches to tumours of the pineal region
  • Surgical anatomy
  • Surgical techniques
  • Complications
  • 3. Stereotactic biopsy
  • XI. Chemotherapy for CNS GCTs
  • 1. Overall view of chemotherapy for CNS GCTs
  • 2. Chemotherapy for recurrent CNS GCTs
  • 3. Chemotherapy for newly-diagnosed CNS GCTs: neoadjuvant chemotherapy
  • 4. Chemotherapy - only trials
  • 5. Predictors of outcome to treatment
  • 6. Myeloablative chemotherapy followed by autologous stem cell rescue for CNS GCTs
  • 7. A view of the future
  • XII. Radiotherapy for CNS GCTs
  • 1. “Diagnostic radiotherapy” or radiation test
  • 2. Radiotherapy for CNS germinoma
  • 3. Irradiation volume and technique
  • 4. Radiotherapy for CNS non-germinomatous GCTs
  • 5. Stereotactic irradiation (STI)
  • 6. Future remarks
  • XIII. Adverse effect of therapy and late sequelae in survivors
  • 1. Effect of external radiotherapy
  • 2. Induction of secondary tumors after irradiation
  • 3. Hypothalamic-pituitary dysfunction and their management
  • 4. Ototoxicity of chemotherapy
  • 5. Clinical significance of pineal gland dysfunction.

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