Molecular and Clinical Advances in Anticancer Drug Resistance

Molecular and Clinical Advances in Anticancer Drug Resistance edited by Robert F. Ozols.

The importance of drug resistance in cancer chemotherapy cannot be over­ stated. The 500,000 patients who die every year from cancer in the United States have, in most cases, been treated with chemotherapy. Many of these patients responded initially to chemotherapy, but death resulted from the devel...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Ozols, Robert F. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer US : Imprint: Springer, 1991.
Edition:1st ed. 1991.
Series:Cancer Treatment and Research, 57
Springer eBook Collection.
Subjects:
Oncology  .
Pharmacology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1. New Mechanisms of Gene Amplification in Drug Resistance (The Episome Model)
  • 2. DNA-Damage Inducible Genes
  • 3. Molecular Biology of P-Glycoprotein
  • 4. Resistance to Inhibitors of DNA Topoisomerases
  • 5. Expression of the MDR1 Gene in Human Cancers
  • 6. Immunoblot Detection of P-Glycoprotein in Human Tumors and Cell Lines
  • 7. Modulators of P-Glycoprotein-Associated Multidrug Resistance
  • 8. Clinical Implications of Multidrug Resistance to Chemotherapy
  • 9. The Role of P-Glycoprotein in Drug-Resistant Hematologic Malignancies
  • 10. DNA Repair in Drug Resistance: Studies on the Repair Process at the Level of the Gene
  • 11. Mechanisms of Resistance to Cisplatin
  • 12. The Role of Metallothioneins in Anticancer Drug Resistance
  • 13. Modulation of Antitumor Alkylating Agents (AA).

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