The Molecular Biology of Down Syndrome

The Molecular Biology of Down Syndrome edited by G. Lubec.

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Lubec, G. (Editor)
Format: eBook
Language:English
Published: Vienna : Springer Vienna : Imprint: Springer, 1999.
Edition:1st ed. 1999.
Series:Journal of Neural Transmission. Supplementa, 57
Springer eBook Collection.
Subjects:
Neurosciences.
Molecular biology.
Human genetics.
Pediatrics.
Pathology.
Psychiatry.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Molecular abnormalities of the brain in Down Syndrome: relevance to Alzheimer’s neurodegeneration
  • Reduced aldehyde dehydrogenase levels in the brain of patients with Down Syndrome
  • The Down Syndrome critical region
  • Neuropathology
  • c-fos expression in brains of patients with Down Syndrome
  • Neuronal cell death in Down’s syndrome
  • Altered Gene expression in fetal Down Syndrome brain as revealed by the Gene huntinG technique of subtractive hybridization
  • Gene expression in fetal Down Syndrome brain as revealed by subtractive hybridization
  • Molecular misreadinG of Genes in Down syndrome as a model for the Alzheimer type of neurodegeneration
  • Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer’s disease brain is downregulated at the mRNA and dysregulated at the protein level
  • Gene expression relevant to Down Syndrome: problems and approaches
  • Isolation and analysis of chromosome 21 Genes potentially involved in Down Syndrome
  • Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down Syndrome
  • Serotonin (5-HT) in brains of adult patients with Down Syndrome
  • Mechanisms of neuronal death in Down’s syndrome
  • Impaired brain Glucose metabolism in patients with Down Syndrome
  • Oxidative stress and neural dysfunction in Down Syndrome
  • Expression of the transcription factor ETS2 in brain of patients with Down Syndrome — evidence against the overexpression-Gene dosage hypothesis
  • Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down Syndrome
  • The “Gene dosage effect” hypothesis versus the “amplified developmental instability” hypothesis in Down Syndrome
  • Downregulation of the transcription factor scleraxis in brain of patients with Down Syndrome
  • Heat-shock protein 70 levels in brain of patients with Down Syndrome and Alzheimer’s disease
  • Increased levels of 14-3-3 Gamma and epsilon proteins in brain of patients with Alzheimer’s disease and Down Syndrome
  • Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin
  • Overexpression of DNAse I in brain of patients with Down Syndrome.

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