The Macrophage as Therapeutic Target

The Macrophage as Therapeutic Target edited by Siamon Gordon.

During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from geneticall...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Gordon, Siamon (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2003.
Edition:1st ed. 2003.
Series:Handbook of Experimental Pharmacology, 158
Springer eBook Collection.
Subjects:
Immunology.
Pharmacology.
Virology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • List of Contents
  • 1. General
  • The Macrophage as a Validated Pharmaceutical Target
  • Transcription Factors that Regulate Macrophage Development and Function
  • Exploitation of Macrophage Clearance Functions In Vivo
  • Reaching the Macrophages: Routes of Delivery
  • Antigen Presenting Cells and Vaccine Design
  • Macrophage-Specific Gene Targeting In Vivo
  • 2. Macrophage Targets in Inflammation
  • Integrins of Macrophages and Macrophage-Like Cells
  • Macrophage Targets in Inflammation: Purinergic Receptors
  • Macrophage Lipid Uptake and Foam Cell Formation
  • Dietary Fatty Acids and Macrophages
  • Macrophages as Therapeutic Targets in Lysosomal Storage Disorders
  • Nuclear Receptors as Regulators of Macrophage Homeostasis and Function
  • Relationships between Reactive Oxygen Species and Reactive Nitrogen Oxide Species Produced by Macrophages
  • Proteases
  • Targeting the Chemokine System
  • Antimicrobial Peptides
  • Macrophage Phospholipid Products
  • 3. Modulation of Specialised Macrophage Activities
  • Dendritic Cells Versus Macrophages as Antigen-Presenting Cells: Common and Unique Features
  • The Osteoclast
  • Macrophages in the Central and Peripheral Nervous System
  • Innate Recognition of Viruses by Macrophage and Related Receptors: Potential Ligand for Antiviral Agents
  • Macrophage Immunity and Mycobacterium Tuberculosis
  • Detection and Control of Fungi by Macrophages: The Role of Carbohydrates and Antifungal Agents.

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