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|a 9783642701139
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|a 10.1007/978-3-642-70113-9
|2 doi
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|a (DE-He213)978-3-642-70113-9
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|a Human T-Cell Leukemia Virus
|h [electronic resource] /
|c edited by P.K. Vogt.
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| 250 |
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|a 1st ed. 1985.
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| 264 |
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1 |
|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 1985.
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| 300 |
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|a X, 266 p.
|b online resource.
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| 336 |
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|a text
|b txt
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| 490 |
1 |
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|a Current Topics in Microbiology and Immunology,
|x 0070-217X ;
|v 115
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| 490 |
1 |
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|a Springer eBook Collection
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| 505 |
0 |
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|a Human T-Cell Leukemia/Lymphoma Viruses — An Introduction -- Isolation, Characterization, and Biological Effects of the First Human Retroviruses: The Human T-Lymphotropic Retrovirus Family. With 1 Figure -- Human T-Cell Leukemia/Lymphoma Viruses (HTLV): A Unique Family of Pathogenic Retroviruses. With 2 Figures -- Epidemiology of Adult T-Cell Leukemia/Lymphoma in Japan. With 9 Figures -- Human T-Cell Leukemia/Lymphoma Viruses: Clinical and Epidemiologic Features -- Clinical Aspects of Adult T-Cell Leukemia/Lymphoma -- The Epidemiology of Human T-Cell Leukemia/Lymphoma Virus. With 5 Figures -- Adult T-Cell Leukemia/Lymphoma and Its Clinical Subtypes from the Viewpoints of Viral Etiology -- A Retrovirus Associated with a Human Leukemia, Adult T-Cell Leukemia -- Biology of Human T-Cell Leukemia Virus: Search for an Animal System. With 7 Figures -- Molecular Biology of Human T-Cell Leukemia Virus Associated with Adult T-Cell Leukemia. With 9 Figures -- Structure and Function of the Genome of HTLV. With 7 Figures -- Some Perspectives on the Molecular Mechanism of in Vitro Transformation and in Vivo Leukemogenesis by HTLV. With 3 Figures -- Primary Structure and Processing of gag and env Gene Products of Human T-Cell Leukemia Viruses HTLV-ICR and HTLV-IATK. With 9 Figures -- Envelope Properties of Human T-Cell Leukemia Viruses. With 3 Figures -- Human T-Cell Leukemia/Lymphoma Virus: Studies of Host-Virus Interaction. With 9 Figures.
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| 520 |
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|a characteristic features in common with the genome of other retroviruses: long terminal repeats (L TR), and coding regions for internal proteins (gag), for re verse transcriptase (pol), and for glycosylated virion surface proteins (env) , ar ranged in the sequence gag, pol, env from the 5' to the 3' end of the genome. However, the HTL V genome also contains some specific features not shared with all other retroviruses: the LTR regions are unusually long (745 base pairs, with 298 base pairs constituting the R region), but unlike the long L TRs of mouse mammary tumor viruses, they do not contain open reading frames. A stretch of noncoding sequences separates the gag and the pol genes. Most interestingly, the HTLV genome contains a region between the 3' end of the env gene and the L TR, called the pX region, that encompasses four open reading frames. Leukemic T cells freshly obtained from patients contain the HTL V provirus but usually do not express it. However, once established in culture, these cells produce viral proteins and release type C particles. Likewise, T cells infected and transformed by HTL V in vitro synthesize virus. Such producing cell lines have been widely used in seroepidemiological surveys and continue to be of importance for detailed studies of viral proteins and nucleic acids.
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| 590 |
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|a Loaded electronically.
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| 590 |
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|a Electronic access restricted to members of the Holy Cross Community.
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| 650 |
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|a Medical microbiology.
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| 650 |
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|a Virology.
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| 650 |
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|a Oncology .
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| 690 |
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|a Electronic resources (E-books)
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| 700 |
1 |
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|a Vogt, P.K.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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2 |
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|a SpringerLink (Online service)
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| 830 |
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|a Current Topics in Microbiology and Immunology,
|x 0070-217X ;
|v 115
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|
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|a Springer eBook Collection.
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|u https://holycross.idm.oclc.org/login?auth=cas&url=https://doi.org/10.1007/978-3-642-70113-9
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