Aging at the Molecular Level

Aging at the Molecular Level edited by Thomas von Zglinicki.

During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and main...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: von Zglinicki, Thomas (Editor)
Format: eBook
Language:English
Published: Dordrecht : Springer Netherlands : Imprint: Springer, 2003.
Edition:1st ed. 2003.
Series:Biology of Aging and its Modulation ; 1
Springer eBook Collection.
Subjects:
Cell biology.
Animal anatomy.
Dermatology.
Biochemistry.
Human genetics.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1. Free radical production and antioxidant defense: a primer
  • 2. Oxidative DNA damage and repair — implications for aging
  • 3. Oxidative damage to proteins
  • 4. Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studies
  • 5. Genomic instability in human premature aging
  • 6. Oxidative damage, somatic mutations and cellular aging
  • 7. Mitochondria and aging
  • 8. Biological clocks in the aging cell
  • 9. Telomeric damage in aging
  • 10. Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice
  • 11. Non-oxidative modification of DNA and proteins
  • 12. Transcriptional and translational dysregulation during aging
  • 13. Metabolic regulation of gene silencing and life span
  • 14. The proteasome in aging
  • 15. Aging and lysosomal degradation of cellular constituents.

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