Calcitonin Gene-Related Peptide (CGRP) Mechanisms Focus on Migraine / edited by Susan D. Brain, Pierangelo Geppetti.

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various cha...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Brain, Susan D. (Editor), Geppetti, Pierangelo (Editor)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
Edition:1st ed. 2019.
Series:Handbook of Experimental Pharmacology, 255
Springer eBook Collection.
Subjects:
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1. CGRP Discovery and Timeline
  • 2. CGRP Receptor Biology: Is There More Than One Receptor?
  • 3. The Structure of the CGRP and Related Receptors
  • 4. CGRP Receptor Signalling Pathways
  • 5. Pathways of CGRP Release from Primary Sensory Neurons
  • 6. CGRP in Animal Models of Migraine
  • 7. CGRP in Human Models of Migraine
  • 8. Role of CGRP in Migraine
  • 9. Understanding CGRP and Cardiovascular Risk
  • 10. CGRP and Painful Pathologies other than Headache
  • 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.