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|a 9783030007379
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7 |
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|a 10.1007/978-3-030-00737-9
|2 doi
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|a (DE-He213)978-3-030-00737-9
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|a Prefoldins: the new chaperones
|h [electronic resource] /
|c edited by Nabil Djouder.
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| 250 |
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|a 1st ed. 2018.
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| 264 |
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1 |
|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2018.
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| 300 |
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|a IX, 135 p. 39 illus., 36 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 490 |
1 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 1106
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| 490 |
1 |
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|a Springer eBook Collection
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| 505 |
0 |
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|a Preface -- Structure of the molecular chaperone prefoldin -- Structure and function of archaeal prefoldin -- Role and functions of prefoldins -- Nuclear functions of prefoldins -- The yeast prefoldin Bud27 -- URI-like prefoldin complex -- HSP90 and its R2TP/Prefoldin-like cochaperone -- Role and functions of URI: mouse models for URI -- Nuclear function of URI-like prefoldin complex -- URI and androgen regulation. Index.
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| 520 |
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|a This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.
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| 590 |
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|a Loaded electronically.
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| 590 |
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|a Electronic access restricted to members of the Holy Cross Community.
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| 650 |
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0 |
|a Human genetics.
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| 650 |
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|a Molecular biology.
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| 650 |
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|a Cell biology.
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| 650 |
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|a Cancer research.
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| 650 |
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|a Proteins .
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| 690 |
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|a Electronic resources (E-books)
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| 700 |
1 |
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|a Djouder, Nabil.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 830 |
|
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 1106
|
| 830 |
|
0 |
|a Springer eBook Collection.
|
| 856 |
4 |
0 |
|u https://holycross.idm.oclc.org/login?auth=cas&url=https://doi.org/10.1007/978-3-030-00737-9
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