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|a 10.1007/978-3-030-02816-9
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|a HIV-1 Latency
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|c edited by Guido Silvestri, Mathias Lichterfeld.
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|a 1st ed. 2018.
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2018.
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| 300 |
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|a VII, 248 p.
|b online resource.
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|a Current Topics in Microbiology and Immunology,
|x 0070-217X ;
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|a Springer eBook Collection
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|a Molecular Control of HIV and SIV Latency -- Assays to Measure Latency, Reservoirs and Reactivation -- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir -- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy -- SIV Latency in Macrophages in the CNS -- Mathematical models of HIV latency -- Residual Immune Activation and Latency -- Immune Interventions to Eliminate the HIV Reservoir -- Cell and Gene Therapy for HIV Cure.
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| 520 |
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|a This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
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| 590 |
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|a Loaded electronically.
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| 590 |
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|a Electronic access restricted to members of the Holy Cross Community.
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| 650 |
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|a Immunology.
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| 650 |
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|a Virology.
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| 650 |
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|a Pathology.
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| 650 |
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|a Epidemiology.
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| 690 |
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