Design and Analysis of Vaccine Studies

Design and Analysis of Vaccine Studies by M. Elizabeth Halloran, Ira M. Longini, Jr., Claudio J. Struchiner.

Widespread immunization has many different kinds of effects in individuals and populations, including in the unvaccinated individuals. The challenge is in understanding and estimating all of these effects. This book presents a unified conceptual framework of the different effects of vaccination at t...

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Bibliographic Details
Main Authors: Halloran, M. Elizabeth (Author), Longini, Jr., Ira M. (Author), Struchiner, Claudio J. (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2010.
Edition:1st ed. 2010.
Series:Statistics for Biology and Health,
Springer eBook Collection.
Subjects:
Health informatics.
Epidemiology.
Infectious diseases.
Statistics .
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • and Examples
  • Overview of Vaccine Effects and Study Designs
  • Immunology and Early Phase Trials
  • Binomial and Stochastic Transmission Models
  • and Deterministic Models
  • Evaluating Protective Effects of Vaccination
  • Modes of Action and Time-Varying VE
  • Further Evaluation of Protective Effects
  • Vaccine Effects on Post-Infection Outcomes
  • Household-Based Studies
  • Analysis of Households in Communities
  • Analysis of Independent Households
  • Assessing Indirect, Total, and Overall Effects
  • Randomization and Baseline Transmission
  • Surrogates of Protection.

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