Polymyxin Antibiotics: From Laboratory Bench to Bedside

Polymyxin Antibiotics: From Laboratory Bench to Bedside edited by Jian Li, Roger L. Nation, Keith S. Kaye.

This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researc...

Full description

Saved in:
Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Li, Jian (Editor), Nation, Roger L. (Editor), Kaye, Keith S. (Editor)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
Edition:1st ed. 2019.
Series:Advances in Experimental Medicine and Biology, 1145
Springer eBook Collection.
Subjects:
Bacteriology.
Pharmacotherapy.
Drug resistance.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Overview
  • Multidrug resistant Gram-negative pathogens: the urgent need for ‘old’ polymyxins
  • Discovery, antibacterial spectrum and chemistry
  • Mechanisms of antibacterial activity
  • Mechanisms of resistance
  • Bioanalysis and stability of polymyxins
  • In vitro pharmacodynamics and PK/PD in animals
  • Antibacterial susceptibility breakpoints
  • Labeling of parenteral products of colistin methanesulfonate
  • Meta-analysis of polymyxin use in patients
  • Clinical use of colistin
  • Clinical use of polymyxin B
  • Pharmacokinetics, pharmacodynamics, toxicodynamics and dosing recommendations
  • Rational combinations with other antibiotics
  • Toxicities in patients: management and mechanisms
  • Antiendotoxin effect
  • Discovery of novel polymyxin-like antibiotics
  • Conclusion.

Similar Items