Drug Resistance in Leishmania Parasites Consequences, Molecular Mechanisms and Possible Treatments

Drug Resistance in Leishmania Parasites Consequences, Molecular Mechanisms and Possible Treatments / edited by Alicia Ponte-Sucre, Maritza Padrón-Nieves.

Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Ponte-Sucre, Alicia (Editor), Padrón-Nieves, Maritza (Editor)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
Edition:2nd ed. 2018.
Series:Springer eBook Collection.
Subjects:
Drug resistance.
Infectious diseases.
Pharmaceutical technology.
Vaccines.
Parasitology.
Microbiology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Prologue
  • Introduction
  • Part I Determinant features in Leishmaniasis
  • Molecular evolution and phylogeny of Leishmania
  • The role of reservoirs: canine Leishmaniasis
  • Epidemiology of Leishmaniasis in the time of drug resistance
  • The role of the immune system in resistance to infection
  • Part II Challenges in the diagnosis, treatment and control of Leishmaniasis in the times of drug resistance
  • Co-infection with HIV
  • Visceral Leishmaniasis
  • Tegumentary Leishmaniasis
  • Antimony accounted sequel post Kala-Azar dermal Leishmaniasis
  • Part III Molecular featrues of drug resistant Leishmania
  • Genetic Expression and drug resistance, the role of proteomics
  • The role of AMC transporters in drug-resistant Leishmania
  • Functional analysis of Leishmania membrane (non AMC) transporters involved in drug resistance
  • Part IV Pharmacology and chemotherapy of Leishmaniasis
  • Classical vs. novel treatment regimens
  • Bioinformatics in Leishmania drug design
  • Leishmanis mitochondria, a druggable organelle
  • P-glycoprotein-like transporters in Leishmania: a search for reversal agents
  • Part V Strategies to circumvent drug resistance in Leishmania
  • The relevance of susceptibility tests, breakpoints and markers
  • The concept of fitness in Leishmania.

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