Targeting Trafficking in Drug Development

Targeting Trafficking in Drug Development edited by Alfredo Ulloa-Aguirre, Ya-Xiong Tao.

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are exp...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Ulloa-Aguirre, Alfredo (Editor), Tao, Ya-Xiong (Editor)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
Edition:1st ed. 2018.
Series:Handbook of Experimental Pharmacology, 245
Springer eBook Collection.
Subjects:
Pharmacology.
Cell biology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1. Intracellular trafficking of gonadotropin receptors in health and disease
  • 2. Investigating internalization and intracellular trafficking of GPCRs
  • 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors
  • 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases
  • 5. Pharmacoperones for misfolded gonadotropin receptors
  • 6. Pharmacological chaperones: Beyond conformational disorders
  • 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer
  • 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches
  • 9. Conserved oligomeric Golgi and neuronal vesicular trafficking
  • 10. SLC6 transporter folding diseases and pharmacochaperoning
  • 11. The molecular physiopathogenesis of islet amyloidosis
  • 12. Folding defects leading to primary hyperoxaluria
  • 13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. .

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