|
|
|
|
| LEADER |
00000nam a22000005i 4500 |
| 001 |
b3276018 |
| 003 |
MWH |
| 005 |
20191023212427.0 |
| 007 |
cr nn 008mamaa |
| 008 |
100301s2006 gw | s |||| 0|eng d |
| 020 |
|
|
|a 9783540272786
|
| 024 |
7 |
|
|a 10.1007/b138868
|2 doi
|
| 035 |
|
|
|a (DE-He213)978-3-540-27278-6
|
| 050 |
|
4 |
|a E-Book
|
| 072 |
|
7 |
|a PSBC
|2 bicssc
|
| 072 |
|
7 |
|a SCI007000
|2 bisacsh
|
| 072 |
|
7 |
|a PSB
|2 thema
|
| 100 |
1 |
|
|a Nölting, Bengt.
|e author.
|4 aut
|4 http://id.loc.gov/vocabulary/relators/aut
|
| 245 |
1 |
0 |
|a Protein Folding Kinetics
|h [electronic resource] :
|b Biophysical Methods /
|c by Bengt Nölting.
|
| 250 |
|
|
|a 2nd ed. 2006.
|
| 264 |
|
1 |
|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 2006.
|
| 300 |
|
|
|a XVI, 222 p. 170 illus., 12 illus. in color.
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 347 |
|
|
|a text file
|b PDF
|2 rda
|
| 490 |
1 |
|
|a Springer eBook Collection
|
| 505 |
0 |
|
|a Structures of proteins -- Physical interactions that determine the properties of proteins -- Calculation of the kinetic rate constants -- High kinetic resolution of protein folding events -- Kinetic methods for slow reactions -- Resolution of protein structures in solution -- High structural resolution of transient protein conformations -- Experimental problems of the kinetic and structural resolution of reactions that involve proteins -- The folding pathway of a protein (barstar) at the resolution of individual residues from microseconds to seconds -- Highly resolved folding pathways and mechanisms of six proteins -- Structural determinants of the rate of protein folding -- Evolutionary computer programming of protein structure and folding -- Conclusions.
|
| 520 |
|
|
|a The book gives a deep insight into the principles and concepts of the kinetic and structural resolution of fast chemical and biophysical reactions of proteins with emphasis on protein-folding reactions. The study of fast protein-folding reactions and the understanding of the folding paradox have significantly advanced due to the recent development of new biophysical methods which allow not only kinetic resolution in the sub-millisecond time scale but also structural resolution with unprecedented precision. Pathways and structures of early and late folding events and the transition state structures of fast- and ultrafast-folding proteins can now be studied in far more detail. Important techniques include biophysical, chemical, molecular biological and mathematical methods, in particular protein engineering, Phi-value analysis, time-resolved circular dichroism, optical triggers and pulsed infrared LASER methods, pressure and temperature jump, ultrafast mixing, stopped flow and quenched flow, dielectric relaxation and electric-field-jump, acoustic relaxation, fluorescence- and isotope-labeling, H/D exchange methods, NMR line broadening and stopped-flow NMR, transition state theory, solutions of rate equations, and evolutionary computer programming. Protein Folding Kinetics - Biophysical Methods is written for students and researchers in biochemistry, biophysics, and related fields. Special features in the second edition: • Includes detailed information and 12 color figures on the high resolution of folding transition states. • Discusses structural determinants of the rate of protein folding on a timescale from microseconds to seconds. • Provides information on self-evolving computer programs for protein-folding simulations and protein-structure predictions.
|
| 590 |
|
|
|a Loaded electronically.
|
| 590 |
|
|
|a Electronic access restricted to members of the Holy Cross Community.
|
| 650 |
|
0 |
|a Proteins .
|
| 650 |
|
0 |
|a Biochemistry.
|
| 650 |
|
0 |
|a Biophysics.
|
| 650 |
|
0 |
|a Biological physics.
|
| 650 |
|
0 |
|a Biotechnology.
|
| 650 |
|
0 |
|a Food—Biotechnology.
|
| 690 |
|
|
|a Electronic resources (E-books)
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 830 |
|
0 |
|a Springer eBook Collection.
|
| 856 |
4 |
0 |
|u https://holycross.idm.oclc.org/login?auth=cas&url=https://doi.org/10.1007/b138868
|3 Click to view e-book
|t 0
|
| 907 |
|
|
|a .b32760188
|b 04-18-22
|c 02-26-20
|
| 998 |
|
|
|a he
|b 02-26-20
|c m
|d @
|e -
|f eng
|g gw
|h 0
|i 1
|
| 912 |
|
|
|a ZDB-2-SBL
|
| 950 |
|
|
|a Biomedical and Life Sciences (Springer-11642)
|
| 902 |
|
|
|a springer purchased ebooks
|
| 903 |
|
|
|a SEB-COLL
|
| 945 |
|
|
|f - -
|g 1
|h 0
|j - -
|k - -
|l he
|o -
|p $0.00
|q -
|r -
|s b
|t 38
|u 0
|v 0
|w 0
|x 0
|y .i21891801
|z 02-26-20
|
| 999 |
f |
f |
|i 62992988-d7f0-53f6-a611-6d5c56f303f9
|s d47310df-4816-573e-85fc-da2f050f767f
|t 0
|
| 952 |
f |
f |
|p Online
|a College of the Holy Cross
|b Main Campus
|c E-Resources
|d Online
|t 0
|e E-Book
|h Library of Congress classification
|i Elec File
|