|
|
|
|
| LEADER |
00000nam a22000005i 4500 |
| 001 |
b3278526 |
| 003 |
MWH |
| 005 |
20191026032803.0 |
| 007 |
cr nn 008mamaa |
| 008 |
100301s2005 sz | s |||| 0|eng d |
| 020 |
|
|
|a 9783764373795
|
| 024 |
7 |
|
|a 10.1007/3-7643-7379-2
|2 doi
|
| 035 |
|
|
|a (DE-He213)978-3-7643-7379-5
|
| 050 |
|
4 |
|a E-Book
|
| 072 |
|
7 |
|a MMBP
|2 bicssc
|
| 072 |
|
7 |
|a MED093000
|2 bisacsh
|
| 072 |
|
7 |
|a MKAL
|2 thema
|
| 245 |
1 |
0 |
|a Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation
|h [electronic resource] /
|c edited by Annika B. Malmberg, Keith R. Bley.
|
| 250 |
|
|
|a 1st ed. 2005.
|
| 264 |
|
1 |
|a Basel :
|b Birkhäuser Basel :
|b Imprint: Birkhäuser,
|c 2005.
|
| 300 |
|
|
|a XII, 249 p.
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 347 |
|
|
|a text file
|b PDF
|2 rda
|
| 490 |
1 |
|
|a Progress in Inflammation Research,
|x 0379-0363
|
| 490 |
1 |
|
|a Springer eBook Collection
|
| 505 |
0 |
|
|a Historical perspective on capsaicin and its receptor -- Hot peppers, pain and analgesics -- Molecular and cellular properties of vanilloid receptors -- Structural determinants of TRPV1 functionality -- TRPV1 distribution and regulation -- Pharmacology and physiology of vanilloid receptors -- Insights into TRPV1 pharmacology provided by non-capsaicin ligands -- Endocannabinoids and vanilloid TRPV1 receptors -- Vanilloid receptor-mediated hyperalgesia and desensitization -- Capsaicin in human experimental pain models of skin, muscle and visceral sensitization -- Vanilloid receptor involvement in disease states -- TRPV1 in gut function, abdominal pain and functional bowel disorders -- TRPV1 in the airways -- Therapeutic potential of vanilloid agonists and antagonists -- TRPV1 agonist-based therapies: mechanism of action and clinical prospects -- TRPV1 agonist therapies in bladder diseases -- TRPV1 antagonists and chronic pain.
|
| 520 |
|
|
|a Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.
|
| 590 |
|
|
|a Loaded electronically.
|
| 590 |
|
|
|a Electronic access restricted to members of the Holy Cross Community.
|
| 650 |
|
0 |
|a Pain medicine.
|
| 650 |
|
0 |
|a Immunology.
|
| 650 |
|
0 |
|a Neurosciences.
|
| 650 |
|
0 |
|a Pharmacology.
|
| 650 |
|
0 |
|a Cell biology.
|
| 690 |
|
|
|a Electronic resources (E-books)
|
| 700 |
1 |
|
|a Malmberg, Annika B.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
|
| 700 |
1 |
|
|a Bley, Keith R.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 830 |
|
0 |
|a Progress in Inflammation Research,
|x 0379-0363
|
| 830 |
|
0 |
|a Springer eBook Collection.
|
| 856 |
4 |
0 |
|u https://holycross.idm.oclc.org/login?auth=cas&url=https://doi.org/10.1007/3-7643-7379-2
|3 Click to view e-book
|t 0
|
| 907 |
|
|
|a .b32785264
|b 04-18-22
|c 02-26-20
|
| 998 |
|
|
|a he
|b 02-26-20
|c m
|d @
|e -
|f eng
|g sz
|h 0
|i 1
|
| 912 |
|
|
|a ZDB-2-SME
|
| 950 |
|
|
|a Medicine (Springer-11650)
|
| 902 |
|
|
|a springer purchased ebooks
|
| 903 |
|
|
|a SEB-COLL
|
| 945 |
|
|
|f - -
|g 1
|h 0
|j - -
|k - -
|l he
|o -
|p $0.00
|q -
|r -
|s b
|t 38
|u 0
|v 0
|w 0
|x 0
|y .i21916883
|z 02-26-20
|
| 999 |
f |
f |
|i 878d75e2-e512-5ca1-b056-7f8c33333a7f
|s 5f5cc372-de38-5a8e-8480-eeda0fdce3f1
|t 0
|
| 952 |
f |
f |
|p Online
|a College of the Holy Cross
|b Main Campus
|c E-Resources
|d Online
|t 0
|e E-Book
|h Library of Congress classification
|i Elec File
|