PEGylated Protein Drugs: Basic Science and Clinical Applications

PEGylated Protein Drugs: Basic Science and Clinical Applications edited by Francesco M. Veronese.

PEGylated Protein Drugs: Basic Science and Clinical Applications describes the basic technologies and the major results obtained with the PEGylation technique, the covalent binding to proteins, peptides and small organic molecules of the hydrophilic and biocompatible polymer poly(ethylene glycol) to...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Veronese, Francesco M. (Editor)
Format: eBook
Language:English
Published: Basel : Birkhäuser Basel : Imprint: Birkhäuser, 2009.
Edition:1st ed. 2009.
Series:Milestones in Drug Therapy,
Springer eBook Collection.
Subjects:
Pharmacology.
Immunology.
Biotechnology.
Medical biochemistry.
Medicinal chemistry.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Preface PEGylated protein conjugates: A new class of therapeutics for the 21st century
  • Protein PEGylation, basic science and biological applications
  • Reactive PEGs for protein conjugation
  • Rebridging disulphides: site-specific PEGylation by sequential bis-alkylation
  • Enzymatic techniques for PEGylation of biopharmaceuticals
  • The site-specific TGase-mediated PEGylation of proteins occurs at flexible sites
  • Protein conjugates purification and characterization
  • PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals
  • The occurrence, induction, specificity and potential effect of antibodies against poly(ethylene glycol)
  • Pegfilgrastim — designing an improved form of rmetHuG-CSF
  • PEGylation of human growth hormone: strategies and properties
  • PEGylated ? interferons: two different strategies to achieve increased efficacy
  • Development of PEGylated mammalian urate oxidase as a therapy for patients with refractory gout
  • Certolizumab pegol: a PEGylated anti-tumour necrosis factor alpha biological agent
  • PEG: a useful technology in anticancer therapy
  • Regulatory strategy and approval processes considered for PEG-drug conjugates and other nanomedicines.

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