Signaling Pathways and Molecular Mediators in Metastasis

Signaling Pathways and Molecular Mediators in Metastasis edited by Alessandro Fatatis.

This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapte...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Fatatis, Alessandro (Editor)
Format: eBook
Language:English
Published: Dordrecht : Springer Netherlands : Imprint: Springer, 2012.
Edition:1st ed. 2012.
Series:Springer eBook Collection.
Subjects:
Cancer research.
Oncology  .
Medical genetics.
Proteins .
Cytokines.
Growth factors.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Preface.-1. Introduction.I. Local invasion.-2. Reactivation of Epithelial Mesenchymal Transition in Invasive and Metastatic Cancer.-3. Biomechanical ECM Switches and Tumor Metastasis.-4. Moving aggressively: S100A4 and Tumor Invasion
  • 5. Shift in TGF-b-induced signaling as culprit for local invasion and dissemination.-6. Role of Rac1-GEF and Dock180 in mediating tyrosine-kinase stimulated glioma invasion
  • 7. Impact of tumor hypoxia, Src and Met signaling in the dissemination of tumor cells.II. Homing  and colonization at distant sites.-8. Cellular and Molecular Biology of Cancer Cell extravasation
  • 9.  Role of CXCL12 and CXCR4 in tumor biology and metastasis.-10. Transcription factors Stat5a/b and Stat3 in prostate cancer growth and metastases.-11. Survival and growth of early metastatic foci in the bone: Role of the alpha-receptor for Platelet-Derived Growth Factor.-12. Androgen receptor in regulation of prostate cancer progression and metastasis
  • 13. Integrin signaling in angiogenesis and metastatic progression in the brain.-14. Tumor and host determinants of pulmonary metastasis in bladder cancer.-15. The Influence of metastatic breast cancer on the bone microenvironment. Index.

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