Telomeres and Telomerase in Aging, Disease, and Cancer Molecular Mechanisms of Adult Stem Cell Ageing

Telomeres and Telomerase in Aging, Disease, and Cancer Molecular Mechanisms of Adult Stem Cell Ageing / edited by K. Lenhard Rudolph.

The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and ‘health span’ in the growing populations of the elderly. Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumula...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Rudolph, K. Lenhard (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2008.
Edition:1st ed. 2008.
Series:Springer eBook Collection.
Subjects:
Human genetics.
Biochemistry.
Cell biology.
Cancer research.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Telomere Shortening and Ageing
  • Cellular versus Organismal Aging
  • Telomere-Induced Senescence of Primary Cells
  • Telomeres, Senescence, Oxidative Stress, and Heterogeneity
  • Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres
  • Telomerase Mutations and Premature Ageing in Humans
  • Telomerase, Telomeres, and Stem Cell Aging
  • Mechanisms of Stem Cell Ageing
  • Senescence Signatures of Human Hematopoietic Stem Cells
  • Telomere Shortening Induces Cell Intrinsic Checkpoints and Environmental Alterations Limiting Adult Stem Cell Function
  • p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?
  • Telomerase as a Potential Regulator of Tissue Progenitor Cells
  • Telomeres, DNA Damage and Cancer
  • Telomere Shortening and Telomerase Activation during Cancer Formation
  • Telomere Binding Proteins and Disease
  • Therapeutic Targets
  • Targeting Telomerase: Therapeutic Options for Cancer Treatment
  • Werner Syndrome, Telomeres, and Stress Signaling: Implications for Future Therapies?.

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