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|a 9781617793912
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|a 10.1007/978-1-61779-391-2
|2 doi
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|a (DE-He213)978-1-61779-391-2
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|a Diabetes & C-Peptide
|h [electronic resource] :
|b Scientific and Clinical Aspects /
|c edited by Anders A.F. Sima.
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| 250 |
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|a 1st ed. 2012.
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| 264 |
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1 |
|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2012.
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| 300 |
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|a XIII, 169 p. 63 illus., 35 illus. in color.
|b online resource.
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|a Contemporary Diabetes,
|x 2197-7836
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| 490 |
1 |
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|a Springer eBook Collection
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| 505 |
0 |
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|a Preface -- Foreword -- C-peptide and Insulin – A Happy Marriage -- Peptide Interactions of Proinsulin C-peptide -- he Effect of Combined C-peptide and Zinc on Cellular Function -- C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy -- Role of C-Peptide in the Regulation of Microvascular Blood Flow -- Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy? -- Renoprotective Effects of C-Peptide in Type I Diabetes -- The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy -- C-peptide and Type 1 Diabetic Encephalopathy -- C-peptide: a New Molecule with Anti-Inflammatory Properties -- C-peptide: Connecting Diabetes with Macrovascular Complications -- C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes -- Proatherogenic Effects of C-Peptide -- Conclusions and Future Outlook.
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| 520 |
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|a In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide’s physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.
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| 590 |
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|a Loaded electronically.
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| 590 |
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|a Electronic access restricted to members of the Holy Cross Community.
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| 650 |
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|a Endocrinology .
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| 650 |
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|a Diabetes.
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| 650 |
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|a Internal medicine.
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| 690 |
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|a Electronic resources (E-books)
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| 700 |
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|a Sima, Anders A.F.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 710 |
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| 830 |
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|a Contemporary Diabetes,
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