Development of Antibody-Based Therapeutics Translational Considerations

Development of Antibody-Based Therapeutics Translational Considerations / edited by Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp.

Development of Antibody-Based Therapeutics: Translational Considerations examines important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics. Translational strategies for development of antibody-based therapeutics req...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Tabrizi, Mohammad A. (Editor), Bornstein, Gadi G. (Editor), Klakamp, Scott L. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2012.
Edition:1st ed. 2012.
Series:Springer eBook Collection.
Subjects:
Pharmacy.
Pharmacology.
Biochemistry.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Translational Strategies for Development of Antibody-Based Therapeutics: An Overview
  • Discovery Process for Antibody-Based Therapeutics
  • Technologies for the Generation of Human Antibodies
  • Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics
  • Biophysical Considerations
  • Considerations in Establishing Affinity Design Goals
  • BioAnalytical Considerations: Pharmacokinetics and Immunogenicity
  • Antibody-Based Therapeutics in Oncology : Preclinical Considerations
  • Factors Impacting the Tumor Localization and Distribution
  • Antibody-Based Therapeutics: Preclinical Safety Considerations
  • Application of Pharmacokinetic/Pharmacodynamic Modeling
  • Design of Translational Strategies : Application of Population Pharmacokinetic-Pharmacodynamic (PK-PD) Approaches
  • Translational Biomarkers: Essential Tools in Development of Antibody-Based Therapeutics
  • Development of Antibody-Based Therapeutics: Translational Research in Alzheimer’s Disease
  • Considerations in Manufacturing Process Development
  • Next Generation Antibody-Based Therapeutics
  • Immune Complex Therapies for Treatment of Immune Thrombocytopenia (ITP)
  • Application of Bioinformatics Principles for Target Evaluation
  • Concluding Remarks.

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