Protein Kinase C in Cancer Signaling and Therapy

Protein Kinase C in Cancer Signaling and Therapy edited by Marcelo G. Kazanietz.

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor-promoting activity. Phorbol esters had long been of interest to the cancer re...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Kazanietz, Marcelo G. (Editor)
Format: eBook
Language:English
Published: Totowa, NJ : Humana Press : Imprint: Humana, 2010.
Edition:1st ed. 2010.
Series:Current Cancer Research,
Springer eBook Collection.
Subjects:
Cancer research.
Pharmacology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Regulation of PKC Isozyme Function: From Genes to Biochemistry
  • Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective
  • Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids
  • Phorbol Esters and Diacylglycerol: The PKC Activators
  • Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals
  • Regulation of PKC by Protein–Protein Interactions in Cancer
  • PKC Isozymes in the Control of Cell Function
  • Introduction: PKC Isozymes in the Control of Cell Function
  • Regulation and Function of Protein Kinase D Signaling
  • PKC and Control of the Cell Cycle
  • PKC and the Control of Apoptosis
  • Atypical PKCs, NF-?B, and Inflammation
  • PKC Isozymes in Cancer
  • Introduction: PKC and Cancer
  • Protein Kinase C, p53, and DNA Damage
  • PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways
  • PKC–PKD Interplay in Cancer
  • Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer
  • PKC Isozymes and Skin Cancer
  • PKC and Breast Cancer
  • PKC and Prostate Cancer
  • Protein Kinase C and Lung Cancer
  • PKC Isozymes as Targets for Cancer Therapy
  • PKC and Resistance to Chemotherapeutic Agents
  • PKC? as a Target for Chemotherapeutic Drugs
  • Atypical PKCs as Targets for Cancer Therapy.

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