mTOR Pathway and mTOR Inhibitors in Cancer Therapy

mTOR Pathway and mTOR Inhibitors in Cancer Therapy edited by Vitaly A. Polunovsky, Peter J. Houghton.

mTOR Pathway and mTOR Inhibitors in Cancer Therapy provides an up-to-date survey of the rapidly advancing field of cancer therapy. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer trea...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Polunovsky, Vitaly A. (Editor), Houghton, Peter J. (Editor)
Format: eBook
Language:English
Published: Totowa, NJ : Humana Press : Imprint: Humana, 2010.
Edition:1st ed. 2010.
Series:Cancer Drug Discovery and Development,
Springer eBook Collection.
Subjects:
Cancer research.
Cell biology.
Pharmacology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • mTORC1: A Signaling Integration Node Involved in Cell Growth
  • The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions
  • mTOR Signaling in Angiogenesis
  • mTORC1 Signaling and Hypoxia
  • mTOR Signaling in Glioblastoma: Lessons Learned from Bench to Bedside
  • mTOR and Cancer Therapy: General Principles
  • mTOR and Cancer Therapy: Clinical Development and Novel Prospects
  • Drug Combinations as a Therapeutic Approach for mTORC1 Inhibitors in Human Cancer
  • Downstream Targets of mTORC1
  • Downstream of mTOR: Translational Control of Cancer
  • Genome-Wide Analysis of Translational Control
  • Translational Control of Cancer: Implications for Targeted Therapy
  • Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex.

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