Apoptosis, Senescence and Cancer

Apoptosis, Senescence and Cancer edited by David A. Gewirtz, Shawn E. Holt, Steven Grant.

Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and ot...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Gewirtz, David A. (Editor), Holt, Shawn E. (Editor), Grant, Steven (Editor)
Format: eBook
Language:English
Published: Totowa, NJ : Humana Press : Imprint: Humana, 2007.
Edition:2nd ed. 2007.
Series:Cancer Drug Discovery and Development,
Springer eBook Collection.
Subjects:
Radiotherapy.
Cancer research.
Oncology  .
Nuclear medicine.
Pharmacology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • Apoptosis and Alternative Modes of Cell Death
  • The Intrinsic Pathway of Apoptosis
  • The Extrinsic Pathway of Apoptosis
  • Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival
  • Mitotic Catastrophe
  • Autophagy and Autophagic Cell Death
  • Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis
  • Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis
  • Structure and Function of the Telomere
  • Overview of Senescence
  • Contributions of Telomerase to Tumorigenesis
  • The Role of Telomeres in Genomic Instability
  • DNA Damage Response, Signaling Pathways, and Tumorigenesis
  • Overview of the DNA Damage Checkpoint
  • Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancer
  • Interplay Between ?H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Response
  • DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy
  • Resistance and Sensitization
  • Resistance/Signaling Pathways
  • Ceramide and Multidrug Resistance
  • Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling
  • The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy
  • Established Cancer Therapies
  • Antimetabolites
  • Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes
  • Perturbations of Cellular Functions by Topoisomerase II Inhibitors
  • The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs
  • Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents
  • Tyrosine Kinase Inhibitors
  • Recent and Developing Cancer Therapies
  • Monoclonal Antibodies in Lymphomas
  • Role of Apoptosis in Anti-Angiogenic Cancer Therapies
  • Photodynamic Therapy-Induced Apoptosis
  • Modulation of TRAIL Signaling for Cancer Therapy.

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