Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery

Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery / edited by Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus.

This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of p...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Hitomi, Kiyotaka (Editor), Kojima, Soichi (Editor), Fesus, Laszlo (Editor)
Format: eBook
Language:English
Published: Tokyo : Springer Japan : Imprint: Springer, 2015.
Edition:1st ed. 2015.
Series:Springer eBook Collection.
Subjects:
Pharmaceutical technology.
Biochemistry.
Enzymology.
Electronic resources (E-books)
Online Access:Click to view e-book
Holy Cross Note:Loaded electronically.
Electronic access restricted to members of the Holy Cross Community.
Table of Contents:
  • 1 Structure of Transglutaminases. Unique Features Serve Diverse Functions
  • 2 Control of Tg Functions Depending on their Localization
  • 3 Preferred Substrate Structure of Transglutaminases
  • 4 Insights into Transglutaminase 2 Function Gained from Genetically-Modified Animal Models
  • 5 Tranglutaminase in Invertebrates
  • 6 Formation of Integrin-Binding Site on Polymer of Transglutamination
  • 7 Transglutaminase 2-Mediated Gene Regulation
  • 8 The Role of Transglutaminase Type 2 in the Regulation of Autophagy
  • 9 Transglutaminase 2 and Celiac Disease
  • 10 Transglutaminase ii and Metastasis: How Hot is the Link?- 11 Transglutaminases: Expression in Kidney and Relation to Kidney Fibrosis
  • 12 Transglutaminases in Bone Formation and Bone Matrix Stabilization
  • 13 Transglutaminases and Neurological Diseases
  • 14 Transglutaminase; Mechanism by Oxidative Stress
  • 15 Blood Coagulation Factor Xiii : A Multifunctional Transglutaminase
  • 16 Inhibition of Transglutaminase
  • 17 Substrate Engineering of Microbial Transglutaminase for Site-Specific Protein Modification and Bioconjugation.

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